Metabolismo

<p>Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.</p>

<p>Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.</p>

<p>Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.</p>

<p>JW 642 inhibits MAGL in mouse, rat, human brains (IC50: 7.6, 14, 3.7 nM).</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat 25-OH-D protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat 25-OH-D. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Sucralose (Trichlorosucrose), an artificial sweetener, is not degraded by the body, so it is noncaloric.</p>

<p>AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.</p>

<p>Denatonium benzoate, a salt with an inert anion, resembles lidocaine but has a benzyl group on its amino nitrogen.</p>

<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>

<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>

<p>Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.</p>

<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>

<p>Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.</p>

<p>DATPT is a 12WLVSKF17 peptide mimetic molecule with anti-inflammatory and antimicrobial activities.DATPT inhibits the production of reactive oxygen species.</p>

<p>Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.</p>

<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. It can be used in the preparation of disease-modifying antirheumatic drugs (DMARDs).</p>

<p>10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.</p>

<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>

<p>Acipimox (K-9321), a niacin derivative, treats hyperlipidemia in type 2 diabetics.</p>

<p>Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.</p>

<p>Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.</p>

<p>LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>2-Methoxy Phenothiazine is light yellow or light gray solid.</p>

<p>Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with DOPAC protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to DOPAC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of DOPAC in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Gedocarnil（ZK 113315） may be used to study diseases of the central nervous system.Cost-effective and quality-assured.</p>

<p>trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).</p>

<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>

<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>

<p>BCI ((E)-BCI) is an allosteric inhibitor of dual-specificity phosphatase (DUSP; EC50s: 13.3 and 8.0 μM for DUSP6 and DUSP1 in cells) and does not inhibit DUSP5.</p>

<p>3-Pyridylacetic acid HCl (3-PAA) is a strong acid, reactive with amines/alcohols/acids, and an organic catalyst.</p>

<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>

<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>

<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>

<p>Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.</p>

<p>GSK-7975A is a potent and orally available inhibitor of CRAC channel.</p>

<p>Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.</p>

<p>Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.</p>

<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>

<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.</p>

<p>Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits HIF, has antioxidation, anti-inflammation, and anti-tumor effects.</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.</p>

<p>Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established.</p>

<p>H-Lys(Tfa)-OH is an inhibitor of L-lysine cyclodeaminase.</p>

<p>Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.</p>

<p>Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.</p>

<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>

<p>Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.</p>

<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>

<p>Dafadine-A, a dafadine analog, inhibits DAF-9 P450 in C. elegans and mammalian CYP27A1.</p>

<p>Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.</p>

<p>Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) relaxes arterioles and lowers blood pressure in mice.</p>

<p>p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].</p>

<p>Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.</p>

<p>Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).</p>

<p>Diethylcarbamazine citrate treats filariasis, targeting W. bancrofti and L. loa by inhibiting arachidonic acid in microfilaria.</p>

<p>Vasopressin acetate: cyclic nonapeptide synthesized in the hypothalamus, functions as a neurotransmitter via G protein-coupled receptors.</p>

<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>

<p>5-R-Rivaroxaban is the (R)-enantiomer of Rivaroxaban, a potent FXa inhibitor with IC50 0.7 nM and Ki 0.4 nM.</p>

<p>Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。</p>

<p>"SLC26A3-IN-1 inhibits SLC26A3, an anion transporter linked to diarrhea, with 340 nM IC50."</p>

<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>

<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>

<p>AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM).</p>

<p>Abiraterone Acetate (CB7630) is an androstene derivative that inhibits steroid 17-alpha-hydroxylase and is used as an antineoplastic agent.</p>

<p>N1-Acetylspermine trihydrochloride: monoacetylated spermine, aids in bleomycin-A5 uptake studies via SLC22A16.</p>

<p>Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.</p>

<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>

<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>

<p>SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.</p>

<p>Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant</p>

<p>Miglustat (NB-DNJ), derived from deoxynojirimycin, inhibits glucosylceramide synthase to manage Gaucher disease Type I.</p>

<p>Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.</p>

<p>Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate), an active metabolites of norgestimate, is a steroidal progestin used in contraceptive patches.</p>

<p>10,12-Tricosadiynoic acid: orally active ACOX1 inhibitor, treats metabolic diseases by enhancing lipid/ROS metabolism in mitochondria.</p>

<p>PEP 3 CHA: a carbohydrate metabolite with cytoprotection and antioxidant properties; cell membrane permeable.</p>

<p>FASN-IN-3 is an inhibitor of fatty acid synthase (FASN).</p>

<p>GW 7647 is an effective and highly selective PPARα agonist. GW 7647 can reduce the production of nitric oxide in macrophages. Cost-effective and quality-assured.</p>

<p>MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd.</p>

<p>LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by &gt; 6 fold at concentrations &lt; 5 μM after 24 h.</p>

<p>Naringinase, with α-L-rhamnosidase and β-D-glucosidase activities, transforms steroids, antibiotics, and glycosides.</p>

<p>N-(1-Adamantyl)acetamide is used as intermediates for synthesis of amantadine hydrochloride.</p>

<p>Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.</p>

<p>1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>