Metabolism

Candoxatril is an inhibitor neutral endopeptidase (NEP).

Florfenicol amine hydrochloride is a veterinary antibiotic with antimicrobial activity that can be used to study diseases caused by Bartonella henselae.

D-Glucose-13C6 (Dextrose-13C6), a C13 marker, serves as a metabolic tracer and can be used to study metabolism-related diseases in the body.

2-(Methylamino)pentanedioic acid (N-Methyl-DL-glutamic acid) inhibits Glutaminase, adds freshness to edible products, and can be used in tuberculosis research.

Bisoxatin (LA 271A) is an oral laxative that can be used to study contact laxatives for chronic constipation.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse 25-OH-D antigen, and the Mouse 25-OH-D standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Mouse 25-OH-D to each microplate well and incubated . After TMB substrate solution is added, the enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ±10nm. The concentration of Mouse 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.

AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human FE, and the Human FE standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human FE. After TMB substrate solution is added, only those wells that contain Human FE and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human FE in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat ADP, and the Rat ADP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Rat ADP. After TMB substrate solution is added, only those wells that contain Rat ADP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat ADP in the samples is then determined by comparing the OD of the samples to the standard curve.

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat IGFBP7, and the Rat IGFBP7 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Rat IGFBP7. After TMB substrate solution is added, only those wells that contain Rat IGFBP7 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat IGFBP7 in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PSMA, and the Human PSMA standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human PSMA. After TMB substrate solution is added, only those wells that contain Human PSMA and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PSMA in the samples is then determined by comparing the OD of the samples to the standard curve.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Lpa, and the Human Lpa standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human Lpa. After TMB substrate solution is added, only those wells that contain Human Lpa and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Lpa in the samples is then determined by comparing the OD of the samples to the standard curve.

Flumazenil EP Impurity D is a compound that can be used in biochemical experiments as a mitochondrial fusion inhibitor.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse ADP, and the Mouse ADP standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Mouse ADP. After TMB substrate solution is added, only those wells that contain Mouse ADP and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse ADP in the samples is then determined by comparing the OD of the samples to the standard curve.

Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human IGFBP3, and the Human IGFBP3 standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human IGFBP3. After TMB substrate solution is added, only those wells that contain Human IGFBP3 and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human IGFBP3 in the samples is then determined by comparing the OD of the samples to the standard curve.

(±)-1,2-Propanediol (Methyl ethyl glycol) is an aliphatic alcohol that is frequently used as an excipient to improve solubility and stability of drugs.

Fmoc-His-OH (FMOC-L-Histidine) is a histidine derivative and a common material for peptide synthesis.

Hydroxy Itraconazole (R63373) is a triazole compound with antifungal activity for the study of malignant tumors.

This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat 25-OH-D antigen, and the Rat 25-OH-D standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Rat 25-OH-D to each microplate well and incubated . After TMB substrate solution is added, the enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ±10nm. The concentration of Rat 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.

meta-Fexofenadine (meta-MDL-16455) is an isomer of Fexofenadine.

2-Naphthol-d8 is a deuterated compound of 2-Naphthol. 2-Naphthol has a CAS number of 135-19-3. 2-Naphthol is an isomer of 1-naphthol, differing by the location of the hydroxyl group on the naphthalene ring.

Adenylate (Adk), a phosphotransferase enzyme, catalyzes adenosine phosphates and regulates cellular energy.

Benzophenone-13C (carbonyl-13C) is the 13C labeled compound of Benzophenone. Benzophenone has a CAS number of 119-61-9.

Edoxaban-d6 is a deuterated compound of Edoxaban. Edoxaban has a CAS number of 480449-70-5. Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.

Buspirone EP Impurity A-d8 is a deuterated compound of Buspirone EP Impurity A. Buspirone EP Impurity A has a CAS number of 20980-22-7. 2-(1-Piperazinyl)pyrimidine is used as an anti-anxiety drug.

L-Lysine-13C6-15N2 Hydrochloride is a 13C and 15N labeled L-Lysine hydrochloride.

4'-Hydroxy Diclofenac-d4 is a deuterated compound of 4'-Hydroxy Diclofenac. 4'-Hydroxy Diclofenac has a CAS number of 64118-84-9. 4'-Hydroxydiclofenac is a diclofenac metabolite.

Febuxostat-d7 is a deuterated compound of Febuxostat. Febuxostat has a CAS number of 144060-53-7. Febuxostat is a xanthine oxidase Inhibitor.

L-Valine-13C5-15N is the 13C and 15N labeled compound of L-Valine. L-Valine has a CAS number of 72-18-4. A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

Norfloxacin-d8 is a deuterated compound of Norfloxacin. Norfloxacin has a CAS number of 70458-96-7. Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

BISPHENOL-A-2,2',3,3',5,5',6,6'-d8 is a deuterated compound of BISPHENOL-A. BISPHENOL-A has a CAS number of 80-05-7. Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties.

WZB117 inhibits GLUT1; IC50 ~10μM slows A549 lung & MCF7 breast cancer cell growth.

GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor.

Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic gabapentin, offering sustained dose-proportional exposure and predictable bioavailability.

Cysteinylglycine (Cys-Gly), is a biologically important compound since it is formed during the γ-glutamyl cycle. It is a L-cysteinyl peptide, that can be used in the studies of many peptides and important proteins.

5-Hydroxymethylcytosine (5hmC), a modified cytosine, is a sixth base of DNA and aids in active DNA demethylation.

Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation.

Triclofos Sodium is used to treat insomnia and used for sedation.

Eltivutabart, Anti-CD39 mAb, increases extracellular ATP, reduces adenosine, promotes antitumor immunity, for pancreatic cancer.

Raloxifene Bismethyl Ether is a Raloxifene metabolite and an estrogen receptor inactive compound on which both hydroxyl groups are absent.

PHA-782584 is a bio-active chemical.

Cetilistat impurity 1, a pancreatic lipase inhibitor with IC50: 54.8 nM in rats, 5.95 nM in humans.

Dansylleucine is an agent of bioactive chemical.

Rhizopterin is a growth factor for Streptococcus lactis R.

Normetanephrine, an endogenous metabolite found in cerebrospinal fluid, has applications in hypertension research [1] [2].

Apremilast, (+/-)-, is a small molecule inhibitor of phosphodiesterase 4 (PDE4) with oral activity. It is used to treat psoriatic arthritis.