Metabolism

<p>H-DL-Gly-OBzl HCl is a glycine derivative.</p>

<p>Fmoc-L-aspartic acid (Fmoc-Asp-OH) is an aspartic acid derivative.</p>

<p>D-Arginine is inactive form, inhibitor of EC 4.1.1.19 (arginine decarboxylase), toxicity to microorganisms, and acts as a regulator of microbial subpopulation.</p>

<p>H-Asp(OtBu)-OH (L-Aspartic acid 4-tert-butyl ester) is an aspartic acid derivative that can be used for the synthesis of short peptides.</p>

<p>N-Palmitoyl-L-glutamine is a glutamine derivative, with low activity as a substrate for the enzyme PmAcy, which synthesizes n -acyl amino acids.</p>

<p>Mebeverine alcohol is a metabolite of Mebeverine.</p>

<p>Zymosterol—a cholesterol precursor, vital for biosynthesis, mainly in cell membranes.</p>

<p>4-Hydroxyphenyl Carvedilol D5 is the deuterium labeled 4-Hydroxyphenyl Carvedilol.</p>

<p>Clodinafop-propargyl is used to control grass weeds in cereals postemergence, targeting species like Avena and Lolium.</p>

<p>Fmoc-Chg-OH (Fmoc-l-cyclohexylglycine) is a glycine derivative containing an Fmoc protecting group and can be used in peptide synthesis and drug design.</p>

<p>Fmoc-Lys(Alloc)-OH is a lysine derivative containing Fmoc protecting group, which can be used for peptide synthesis and drug design.</p>

<p>Fmoc-Aib-OH (Fmoc-alpha-methylalanine) is an alanine acid derivative, which can be used for peptide synthesis and biopharmaceutical design.</p>

<p>Angiotensin-converting enzyme (Kininase II) is a zinc-dependent peptidase and extracellular enzyme that is a potent vasoconstrictor.</p>

<p>Fmoc-Cha-OH (Fmoc-L-cyclohexylalanine) is an alanine derivative containing an Fmoc protecting group, which can be used for peptide synthesis and drug design.</p>

<p>Fmoc-Lys-OH is a lysine derivative commonly used in the synthesis of active compounds.</p>

<p>Boc-His-OH is a protected amino acid derivative.N-Boc-L-Histidine is used as an intermediate in peptide synthesis with good chemical stability and solubility.</p>

<p>1,3,5-Triisopropylbenzene is commonly used in fuels, lubricants, and micellar expanders, a potential retinoid X nuclear receptor alpha (RXRα) agonist.</p>

<p>3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol. 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].</p>

<p>Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor.</p>

<p>2-Amino-3-(2-chlorophenyl)propanoic acid (2-Chloro-DL-Phenylalanine) is a phenylalanine derivative involved in biometabolism.</p>

<p>Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.</p>

<p>CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

<p>Compound 9j inhibits Glyoxalase I with 1.13 μM IC50, showing anticancer potential and low toxicity.</p>

<p>SN-38 glucuronide, inactive product of Irinotecan, aids in colon/rectal cancer research as a topoisomerase I inhibitor.</p>

<p>Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.</p>

<p>NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ).</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

<p>4-Hydroxypentanoate sodium is a sedative agent and serves as the active metabolite of gamma-Valerolactone.</p>

<p>TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and may be used in the study of idiopathic pulmonary fibrosis.</p>

Acetaminophen metabolite 3-hydroxy-acetaminophen is an antioxidant and a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies.

<p>N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2<br>1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)</p>

<p>Plumbic acetate releases acetate ions, acts as an oxidizer for sulfur (VI) synthesis, and reacts with thiodithiazyl dichloride.</p>

<p>Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.</p>

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone that existed in some fruits from Annonaceae family.</p>

<p>(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a peptide with the sequence Boc-D-Pra-OH and glycine derivative, containing an alkyne group.</p>

<p>H-Tyr-Phe-OH, an orally active peptide, inhibits angiotensin-converting enzyme ACE inhibitory activity and can be used as a biomarker for thyroid nodules.</p>

<p>6-Methyluracil (Pseudothymine): a Uracil metabolite, indicates acetoacetyl-CoA build-up, has antiradiation effects.</p>

<p>L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.</p>

<p>Z-Asn-OH (N-Cbz-L-asparagine) is a glycine derivative mainly used in peptide synthesis.Cbz-Asn-OH prevents unwanted reactions.</p>

<p>XY018 is a ROR-γ antagonist with anti-tumor activity, inhibits ROR-γ activity, and can be used to study drug-resistant prostate cancer.</p>

<p>Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.</p>

<p>2-Amino-3-mercaptopropanoic acid hydrochloride hydrate is a cysteine derivative, widely used in biochemical experiments and drug synthesis research.</p>

<p>Chst15-IN-1 is a selective, reversible covalent Chst15 inhibitor reducing CS-E sulfation, attenuating CSPG effects, and promoting neuronal repair.</p>

<p>ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.</p>

<p>PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.</p>

<p>Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).</p>

<p>PF-05085727 inhibits PDE2A &gt;4,000-fold selectivity over PDE1 and PDE3-11.</p>

<p>BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.</p>