Acids and Synthetic Reagents

<p>Applications Zinc Chloride is a common chemical reagent used in organic syntheses, often alkylation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huo, S. et al.: Org. Lett., 5, 423 (2003);<br></p>

<p>Stability Hygroscopic<br>Applications Bis(tributylammonium) Pyrophosphate is an phosphorylating reagent used in the synthesis of phosphorylated deoxynucleosides.<br>References Santner, T. et al.: Bioorg. Med. Chem, 20, 2416 (2012); Sun, D. et al.: ChemMedChem, 4, 1649 (2009)<br></p>

<p>Stability Shock Sensitive<br>Applications 2,2-Diphenyl-1-picrylhydrazyl is a stable free radical molecule most commonly used as a tool to monitor chemical reactions involving radicals, most notably in antioxidant assay.<br>References Suzhukim K., et al.: J. Org. Chem., 78, 2301 (2013); Chen, Z., et al.: Food. Chem., 138, 414 (2013); Chatterjee, S ., et al.: Advan. BIo. Res., 3, 109 (2012);<br></p>

<p>Applications Dithiothreitol is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol is also used to reduce the disulfide bonds of proteins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, C.-Y. et al.: Langmuir, 21, 5134 (2005); Lu, B.-Y. et al.: Anal. Biochem., 405, 67 (405);<br></p>

<p>Applications 1,8-Diazabicyclo[5.4.0]undec-7-ene, is used in organic synthesis as a catalyst, a complexing ligand, and a non-nucleophilic base. It is also used in a new synthesis of the ABCD ring system of Camptothecin (C175150).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weixiang, D., et al.: Org. Lett., 8(20), 4665 (2006); Regalado, E. L., et al.: Nat. Prod. Commun., 5, 1187 (2010);<br></p>

<p>Applications Coordination compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Galanski, M., et al.: J. Med. Chem., 46, 4946 (2003), Cui, K., et al.: Bioorg. Med. Chem. Lett., 16, 2937 (2006),<br></p>

<p>Applications Ammonium thiocyanate is used in synthetic chemistry as a thiocyanation reagent. Ammonium thiocyanate is also a knwn plant poison and is used as a weed eradicant in the agricultural industry.<br>References Harvey, R.: Agronomy J.: 23, 944 (1931); Sandhoff, A. &amp; Skinner, C.: Soil Sci., 48, 287 (1939); Wu, G., et al.: Tetrahedron Lett., 46, 5831 (2005)<br></p>

<p>Applications (R)-(+)-Citronellic Acid is an oxidized derivative of Citronellal (C525025), a monoterpene compound that is formed by the metabolism of plants.<br>References Brito, R.G., et al.: J. Nat. Med., 66, 637 (2012);<br></p>

<p>Applications Tris Hydrochloride is a high quality buffer component used in SDS-PAGE. Used in the robust generation of transgenic mice.<br>References Usmani, A., et al.: Mol. Ther. Methods Clin. Dev., 3, 16076/1-16076/8 (2016)<br></p>

<p>Applications (R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. (R)-1-Boc-3-hydroxypiperidine has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kikuchi, T., et. al.: J. Labelled Comptd. Rad., 44, 31 (2001); Isakovic, L., et. al.: Bioorg. Med. Chem. Lett., 19, 2742 (2009)<br></p>

<p>Applications Palladium Hydroxide is a catalyst for hydrogenation reactions as well as in the synthesis of glycopeptides used in obtaining antibodies from autoimmune diseases.<br>References Bonache, M. et al.: Adv. Exp. med. Bio., 611, 411 (2009); Dzhardimalieva, G. et al.: Russ. Chem. Bull., 58, 2070 (2009);<br></p>

<p>Applications Potassium Hexacyanoferrate(III) is used in the synthesis of nanocomposite photoadducts.<br>References Rather, M. et al.: Synth. Metal., 179, 60 (2013);<br></p>

<p>Applications Dimethyl Aminoterephthalate is used to prepare imidazotetrazinones as probes for action of temozolomide. It can be used to prepare aminoquinazolines with neurokinin-2 receptor antagonist activity.<br>References Clark, A., et al.: J. Med. Chem., 38, 1493 (1995); Jacobs, R., et al.: Bioorg. Med. Chem. Lett., 5, 2879 (1995)<br></p>

<p>Applications Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.<br>References Emuebie, O. et al: Aus. J. Basic App. Sci., 5, 507 (2011); Cambal, L. et al.: Chem. Res. Toxicol., 24, 1104 (2011); Lam, X. et al.: J. Pharm. Sci., 86, 1250 (1997);<br></p>

<p>Applications 6-O-α-D-Maltosyl-β-cyclodextrin is an additive to improve the solubility of quetiapine.<br>References Ogawa, N., et. al.: Chem. Pharm. Bull., 31, 809 (2013)<br></p>

<p>Applications (R)-(-)-2-Amino-1-propanol is used as a reagent in the synthesis of naphthyridinone integrase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Johns, B.A., et al.: Bioorg. Med. Chem. Lett., 24, 3104 (2014)<br></p>

<p>Applications OCTADECYLTRIETHOXYSILANE (cas# 7399-00-0) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Tris(trimethylsiloxy)silane functions as a modified siloxane elastomer for controlled cell growth or as a biomaterial surface that induces a desired cellular response.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gibson, A. L., et al.: Mater. Res. Soc. Symp. Proc., 711, 169 (2002)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 13-cis-Retinol is one of the active metabolite of Vitamin A (R252000).<br>References Shantz, E., et al.: J. Biol. Chem., 183, A61 (1950), Barua, A., et al.: Biochem. J., 164, 133 (1977), Brouwer, I., et al.: Nutr. Res. Rev., 14, 267 (2001), Grillenberger, M., et al.: Br. J. Nutr., 95, 379 (2006),<br></p>

<p>Applications Phloroglucinol Dihydrate is a reactant used in the synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin.<br>References Sharma, P.K., et. al.: J. Labelled Compd. Rad., 53, 605 (2010)<br></p>

<p>Applications Sodium Pyrophosphate Decahydrate is a tetrabasic pyrophosphate salt used in buffers.<br></p>

<p>Applications Labelled Sodium Cyanoborohydride is a commonly used as a reagent in the reductive amination of aldehydes and ketones and in the reductive alkylation of amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hsu, J. et al.: J. Am. Soc. Mass Spec., 17, 194 (2006); Ducrocq, C. et al.: J. Label. Comp. Radiopharm., 22, 61 (1985);<br></p>

<p>Applications Potassium Bisnonafluoro-1-butanesulfonimidate (cas# 129135-87-1) is a useful research chemical.<br></p>

<p>Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.<br>References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications o-Acetyltoluene can be used as a reagent to prepare diaryl dihydropyrazoles as inhibitors of mitotic kinesin spindle protein (1). It is also used to synthesize aryl- and indolyl-cyanoaminopyridines with anti-inflammatory, analgesic, and antipyretic activities (2).<br>References (1) Cox, C., et al.: Bioorg. Med. Chem. Lett. (2005) 15, 2041 (2) Manna, F., et al.: Eur. J. Med. Chem. (1999) 34, 245-54<br></p>

<p>Stability Hygroscopic<br>Applications (R,R)-Labetalol Hydrochloride is a specific competitive antagonist at both α-and β-adrenergic receptor sites. (R,R)-Labetalol Hydrochloride is also used as an antihypertensive.<br>References Sybertz, E.J., et al.: J. Pharmacol. Exp. Ther., 218, 435 (1981), Clifton, J.E., et al.: J. Med. Chem., 25, 670 (1982), Goa, K.L., et al.: Drugs, 37, 583 (1989),<br></p>

<p>Applications 1-(Bromomethyl)-2-nitrobenzene is a reagent used in the synthesis of 1,3,4-oxadiazole derivatives possessing a benzotriazole moiety leading to anticancer activity. Also used in the preparation of antifungal triazole derivatives.<br>References Zhang, S. et al.: Bioorg. Med. Chem., 21, 3723 (2013); Yu, S. et al.: Arch. Pharm. Res., 36, 1215 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications A bisphosphonate antiresorptive agent; bone resorption inhibitor.<br>References Coukell, A.J., et al.: Drugs Aging, 12, 149 (1998), McTavish, D., et al.: Drugs, 41, 289 (1991), Sissons, C.H., et al.: Oral Microbiol. Immunol., 15, 317 (2000), Chen, J.X., et al.: J. Cell Physiol., 186, 116 (2001),<br></p>

<p>Applications (-)-Dihydroquinine, is a dihydro derivative of Quinine (Q694000), having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties.<br>References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983); Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994);<br></p>

<p>Applications [Bis(diphenylphosphino)ethane]dichloronickel is a coordination complex with potential antitumor activity. It is also used as a fast and efficient hydrogen production catalyst.<br>References Mirabelli, C.K., et al.: J. Med. Chem., 30, 2181 (1987); Gan, L., et al.: J. Am. Chem. Soc., 137, 1109 (2015)<br></p>

<p>Applications An intermediate in the production of Bimatoprost (B386800).<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Glycidoxypropyltrimethoxysilane (cas# 2530-83-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications (R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.<br>References Warren, M.R., et al.: J. Pharmacol. Exp. Ther., 86, 284 (1946); Gaglia, C.A., et al.: Anal. Profiles Drug Subs., 3, 483 (1974);<br></p>

<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Applications Vasodilator, used in treatments for angina.<br>References Miyamoto, S., et al.: Toxicol. Mech. Method., 19, 477 (2009), Perez-Reyes, E., et al.: J. Pharmacol. Exper. Ther., 328, 621(2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethanolamine is an intermediate used to prepare alkynylaryladenines as A2A adenosine receptor agonists and effects on hepatic glucose production. It is also used in the synthesis of functionalized N-arylaminoethyl amides as noncovalent inhibitors of cathepsin S.<br>References Harada, H., et al.: Bioorg. Med. Chem., 9, 2709 (2001); Tully, D., et al.: Bioorg. Med. Chem. Lett., 16, 5112 (2006)<br></p>

<p>Applications Saxagliptin Hydrate is a selective and reversible dipeptidyl peptidase-4 (DPP4) inhibitor that may be used to develop treatment for type 2 diabetes.<br>References Gu, S., et al.: PLoS One. 11, e0167190 (2016); Dave, D. J.: J Pharmacol Pharmacother 2, 230 (2011)<br></p>

<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>

<p>Applications DL-Dapoxetine HCl (cas# 1071929-03-7) is a useful research chemical.<br></p>

<p>Applications Rucaparib is PARP1 inhibitor. It can be used in biological study of chemical screening to identify drugs that enhance or mitigate cellular responses to antibody-toxin fusion proteins using human B cell precursor leukemia cells and cervical adenocarcinoma cells.<br>References Antignani, A., et al.: PLoS One, 11, e0161415/1-e0161415/17 (2016)<br></p>

<p>Applications Benzensulfonic Acid Monohydrate is used in the synthesis of HER2/EFGR dual inhibitors in the treatment of cancers and displaying potency towards anti-tumor activity.<br>References Kawakita, Y. et al.: Bioorg. Med. Chem. Lett., 20, 6171 (2012);<br></p>

<p>Applications A serotonin 5-HT2A receptor antagonist. Used as potential controls in various biological studies.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.F., et al.: Science, 226, 1393 (1984), Blin, J., et al.: Eur. J. Pharmacol., 147, 73 (1988), Kehne, J.H., et al.: J. Pharmacol. Exp. Ther., 277, 968 (1996),<br></p>

<p>Applications Mercury(II) Chloride is used to produce amalgamated aluminium which is used as reducing agent. Mercury(II) Chloride is also used as a catalyst for the conversion of acetylene to vinyl chloride.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Diuguid, L., et al.: J. Am. Chem. Soc., 12,3527 (1941);<br></p>

<p>Applications Deuterated Tolterodine (T535800), a muscarinic receptor antagonist. Used in the treatment of urinary incontinence.<br>References Nilvebrant, L., et al.: Life Sci., 60, 1129 (1997), Nilvebrant, L., et al.: Eur. J. Pharmacol., 327, 195 (1997), Brynne, N., et al.: Int. J. Clin. Pharmacol. Ther., 35, 287 (1997)<br></p>

<p>Applications 2-Bromo-1,4-naphthoquinone is a structural analog of Vitamin K3 (V676130) and has been used in cancer research studies to increase H2O2 production in tumor cell lines.<br>References Graciani, F.S., et al.: Braz. J. Med. Biol. Res., 45, 701 (2012)<br></p>

<p>Applications 5-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derives reagent. Dyes and metabolites.<br>References Theisen, P., et al.: Tetrahedron Lett., 33, 5033 (1992); Mattingly, P.: Bioconjgate Chem., 3, 430 (1992); Bertrand, R., et al.: Biochemistry, 34, 9500 (1995);<br></p>

<p>Applications Sodium Iodide is used in the synthesis of dye-sensitized solar cells. Also used in the preparation of propargylamines as inhibitors of lysine specific. demethylase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zalas, M. et al.: Electrochem. Acta., 108, 736 (2013); Schmitt, M. et al.: J. Med. Chem., 56, 7334 (2013);<br></p>

<p>Applications (R)-(-)-2-Amino-1-butanol (cas# 5856-63-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.<br>References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007),<br></p>

<p>Applications Zinc Nitrate Hexahydrate is a component used in the composition for nourishing and protecting fruit trees from acid rain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blankson, H., et al.: J. Nutr., 130, 2943 (2000), Won, J., et al.: J. Food Sci., 73, N39 (2008),<br></p>

<p>Applications Indigopurpurin is a purple 3,2-bisindole derivative and was shown to exhibit inhibitory allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. A possible glycogen synthase kinase-3 (GSK-3) inhibitor the active component of a traditional Congolese antiepilepsy treatment.<br>References Kim, M.H., et al.: J. Ethnopharmacol., 145, 214 (2013); Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Hsieh, W.L., et al.: J. Dermatol. Sci., 67, 140 (2012); Chem. and Eng. News page 6 Nov. 10 (2018)<br></p>

<p>Stability Hygroscopic<br>Applications The R-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>

<p>Applications Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).<br>References Baker, W. &amp; White, W.: Pharmacotherapy, 45, 1506 (2011); Cushman, W., et al.: Hypertension, 60, 310 (2012); Lastra, G., et al.: Cardio. Med. 3, 154 (2013); Miura, S., et al.: Hypertens. Res., 36, 134 (2012); Rakugi, H., et al.: Hypertens. Res., 35, 552 (2012)<br></p>

<p>Stability Air Sensitive<br>Applications Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents. Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, T.R. et al.: Bull. Kor. Chem. Soc., 3, 162 (1982); Badr, M.Z.A. et al.: Bull. Chem. Soc. Jap., 56, 326 (1983); Langler, R.F. et al.: Can. J. Chem., 57, 3193 (1979);<br></p>

<p>Applications 1,5-Diazabicyclo[4.3.0]non-5-ene is used as a nucleophilic catalyst for the Freidel-Crafts C-acylation of pyrroles and indoles. 1,5-Diazabicyclo[4.3.0]non-5-ene is also an inhibitor of indoleamine-N-methyltransferase (II) of rabbit lung in vitro.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mandel, L.: Biochem. Pharmacol., 25, 2251 (1976); Taylor, J., et al.: Org. Lett., 12, 5740 (2010)<br></p>

<p>Applications Ethylamine is used as a reagent in the synthesis of a series of hexadentate ligands as potential antibacterial agents. Also used as a reagent in the synthesis of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M., et al.: Chem. Biol. Drug Des., 84, 659 (2014); Ma, H., et al.: Eur. J. Med. Chem., 89, 721 (2015)<br></p>

<p>Applications Ammonium Iron(II) Sulfate Hexahydrate (Mohr’s Salt) is used in analytical chemistry allowing products to resist oxidation. In addition it is used in the measurement of high doses of gamma rays.<br>References Hickman, C. et al.: Rad. Prot. Dent., 17, 255 (1986);<br></p>

<p>Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.<br>References Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013);<br></p>

<p>Applications PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),<br></p>

<p>Applications 1,4-Dihydropyridine calcium antagonist with antihypertensive and diuretic effects. A potential candidate in the treatment of patients with renal parenchymal hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohya, Y. et al.: Int. J. Clin. Pharmacol. Therap., 38, 304 (2000); Huh, W. S. et al.: Curr. Therap. Res., 61, 395 (2000); Katoh, M. et al.: Eur. J. Clin. Pharmacol., 55, 843 (2000);<br></p>

<p>Applications Iron(III) Chloride is commonly employed as a Lewis acid for catalysing reactions such as chlorination of aromatic compounds and Friedel-Crafts reaction of aromatics. In industrial application, iron(III) chloride is used in sewage treatment and drinking water production. It is also used as a leaching agent in chloride hydrometallurgy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cox, D., et al.: J. Am. Chem. Soc., 110, 8085 (1988); Tauxe-Wuersch, A., et al.: Water Res., 39, 1761 (2005); Trebouet, D., et al.: Water Res., 35, 2935 (2001)<br></p>

<p>Applications A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, S. et al.: Nature, 461, 614 (2009); Wang, H. et al.: ACS Chem. Biol., 6, 192 (2011); Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009);<br></p>

<p>Applications Sodium Cyanate is used in biological study as tumor cell proliferation and metabolism inhibition.<br>References Hu, J. J., et al.: Cancer Chemoth. Pharm., 26, 269 (1990);<br></p>

<p>Applications Aliquat 336 is a reagent in the synthesis of Iso Promethazine (I822500, HCl); an impurity of Promethazine (P757000, HCl) which is an antihistaminic, antiemetic, and CNS depressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gasco, M.R., et al.: J. Pharma. Sci., 68, 612 (1979); Edge, W., et al.: J. Pharm. Pharmacol., 5, 279 (1953); Huang, et al.: J. Pharm. Sci., 59, 772 (1970); Shearer, C.M., et al.: Anal. Profiles Drug Subs., 5, 429 (1976)<br></p>

<p>Applications Naloxone is a specific opioid antagonist. Narcotic antagonist.<br>References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993),<br></p>

<p>Applications Sodium salt of Ethylenediamine-N,N,N’,N’-tetraacetic Acid (EDTA) a powerful chelating agent; EDTA forms stable complexes with most metal ions. EDTA is used in treatment of lead and heavy metal poisoning of farm animals.<br>References Heindorff, K., et al.: Mutat. Res., 115, 149 (1983); Grier, M.T., et al.: Ann. Pharmacother., 27, 1504 (1993); Krokidis, A.A., et al.: Anal. Chim. Acta, 535, 57 (2005);<br></p>

<p>Stability Hygroscopic<br>Applications Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).<br>References Clayton, R.N., et al.: Clin. Endocrinol., 22, 453 (1985), Gerris, J., et al.: Horm. Res., 45, 279 (1996),<br></p>

<p>Applications Calcium Oxide is an exothermic reagent used in the synthesis of polymers and ceramics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, S. et al.: Mat. Lett., 175, 135 (2016); Dae, J. et al.: J. App. Polym. Sci., 133, (2016);<br></p>

<p>Applications Potassium Ferrocyanide Trihydrate functions in the DNA-binding, cytotoxicity, cellular uptake, apoptosis and photocleavage studies of ruthenium(II) complexes.<br>References Deepika, N., et al.: J. Photochem. Photobiol., B: Biol., 160, 142 (2016)<br></p>

<p>Applications Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.<br>References Pertovaara A., CNS Drug Reviews 11 (3), 273 (2005);<br></p>

<p>Stability Light Sensitive<br>Applications Farnesone is s useful building block for organic synthesis<br></p>

<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications Tetrakis(triphenylphosphine)palladium(0) is widely used as a catalyst for palladium-catalyzed coupling reactions.<br>References Malatesta. L., et al.: J. Chem. Soc., 1186 (1957);<br></p>

<p>Stability Hygroscopic<br>Applications Mn(III) meso-Tetra (N-Methyl-4-pyridyl) Porphine Pentachloride is a synthetic, Manganese (III) porphyrin.<br></p>

<p>Applications (S)-α,α-Bis[3,5-di(trifluoromethyl)phenyl]-O-(trimethylsilyl)pyrrolidine-2-methanol, is a diarylprolinol silyl ether organocatalyst. It is able to catalyze a variety of bond-forming reactions such as C-C, C-N, C-O, C-S, and C-Hal in high yields and excellent levels of enantiocontrol.<br>References Jensen KL, et al. Accounts of Chemical Research 45(2), 248-264, (2011);<br></p>

<p>Applications (R)-2-Hydroxybutanoic acid (cas# 20016-85-7) is a useful research chemical.<br></p>