GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

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GANT 58
CAS:
- 64048-12-0
GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
Formula:C₂₄H₁₆N₄S
Purity:99.53%
Color and Shape:Solid
Molecular weight:392.48
Ref: TM-T15370
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CGS 15943
CAS:
- 104615-18-1
CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.
Formula:C₁₃H₈ClN₅O
Purity:97.4%
Color and Shape:Solid
Molecular weight:285.69
Ref: TM-T14944
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Granisetron hydrochloride
CAS:
- 107007-99-8
Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy
Formula:C₁₈H₂₅ClN₄O
Purity:99.88% - 99.93%
Color and Shape:White To Off-White Crystalline Solid
Molecular weight:348.87
Ref: TM-T1042
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Anatibant 2HCl
CAS:
- 209788-45-4
Anatibant 2HCl is a small molecule bradykinin B2 receptor antagonist for the treatment of neurological disorders and may be used in the study of brain injury.
Formula:C₃₄H₃₆Cl₂N₆O₅S·2ClH
Purity:99.17% - 99.58%
Color and Shape:Soild
Molecular weight:784.58
Ref: TM-T26627L
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YNT-185
CAS:
- 1804978-81-1
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,
Formula:C₃₃H₃₇N₅O₅S
Purity:99.67%
Color and Shape:Solid
Molecular weight:615.74
Ref: TM-T39229
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Desipramine hydrochloride
CAS:
- 58-28-6
Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine.
Formula:C₁₈H₂₃ClN₂
Purity:99.58% - 99.94%
Color and Shape:White To Off-White Powder
Molecular weight:302.842
Ref: TM-T0991
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Urocortin (rat) acetate
Urocortin (rat) acetate: CRF receptor agonist; Ki=13nM (hCRF1), 1.5nM (rCRF2α), 0.97nM (mCRF2β); neuropeptide.
Purity:97.76%
Color and Shape:Soild
Ref: TM-TP1020L
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Linaclotide
CAS:
- 851199-59-2
Linaclotide treats IBS-C & chronic constipation; it's a selective guanylate cyclase C agonist.
Formula:C₅₉H₇₉N₁₅O₂₁S₆
Purity:97.93% - 98.71%
Color and Shape:Solid
Molecular weight:1526.74
Ref: TM-T11852
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DPTN dihydrochloride
CAS:
- 325767-87-1
DPTN dihydrochloride is a potent and selective A3AR antagonist with Ki values of 1.65, 9.61 and 8.53 nM in human, mouse and rat, respectively.
Formula:C₂₂H₂₀Cl₂N₄OS
Purity:99.95%
Color and Shape:Soild
Molecular weight:459.39
Ref: TM-T72067
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Dynarrestin
CAS:
- 2222768-84-3
Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.
Formula:C₂₂H₂₃F₂N₃O₂S
Purity:99.64%
Color and Shape:Solid
Molecular weight:431.5
Ref: TM-T15183
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CYM 50769
CAS:
- 1421365-63-0
CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM).
Formula:C₂₄H₁₇ClN₂O₃
Purity:98% - 99.08%
Color and Shape:Solid
Molecular weight:416.86
Ref: TM-T22702
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Ezlopitant
CAS:
- 147116-64-1
Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.
Formula:C₃₁H₃₈N₂O
Purity:97.49%
Color and Shape:Solid
Molecular weight:454.65
Ref: TM-T68068
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Ciliobrevin D
CAS:
- 1370554-01-0
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor.
Formula:C₁₇H₈Cl₃N₃O₂
Purity:98.09%
Color and Shape:Solid
Molecular weight:392.62
Ref: TM-T14965
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CCR2-RA-[R]
CAS:
- 512177-83-2
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
Formula:C₁₈H₁₉ClFNO₃
Purity:99.7%
Color and Shape:Solid
Molecular weight:351.8
Ref: TM-T14900
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Ketotifen fumarate
CAS:
- 34580-14-8
Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.
Formula:C₂₃H₂₃NO₅S
Purity:99.25% - 99.73%
Color and Shape:Solid
Molecular weight:425.50
Ref: TM-T0994
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Azelastine hydrochloride
CAS:
- 79307-93-0
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
Formula:C₂₂H₂₄ClN₃O·HCl
Purity:98% - >99.99%
Color and Shape:White Crystalline Powder
Molecular weight:418.36
Ref: TM-T0211L
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hGPR91 antagonist 1
CAS:
- 1314796-00-3
hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM).
Formula:C₃₁H₂₃F₄N₃O
Purity:98.89%
Color and Shape:Solid
Molecular weight:529.53
Ref: TM-T11560
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PF-610355 HCl
PF-610355 HCl is a selective and potent β2-adrenergic receptor agonist, a bronchodilator, and for asthma and chronic obstructive pulmonary disease.
Formula:C₁₉H₂₂ClN₇O₆
Purity:97.97%
Color and Shape:Solid
Molecular weight:479.87
Ref: TM-T16509L
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Cloperastine hydrochloride
CAS:
- 14984-68-0
Cloperastine hydrochloride (HT-11 hydrochloride) is a type of flavonoid.
Formula:C₂₀H₂₅Cl₂NO
Purity:97.74% - 99.42%
Color and Shape:Solid
Molecular weight:366.33
Ref: TM-T0723
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Doxepin hydrochloride
CAS:
- 1229-29-4
Doxepin hydrochloride, a dibenzoxepin tricyclic, blocks monoamine reuptake and has anticholinergic and antihistaminic effects. Mechanism partly unknown.
Formula:C₁₉H₂₂ClNO
Purity:99.65% - 99.91%
Color and Shape:White To Off-White Powder
Molecular weight:315.84
Ref: TM-T1540
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Indacaterol maleate
CAS:
- 753498-25-8
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
Formula:C₂₈H₃₂N₂O₇
Purity:99.03% - 99.67%
Color and Shape:Solid
Molecular weight:508.56
Ref: TM-T1239
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ML604086
CAS:
- 850330-18-6
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.
Formula:C₂₇H₃₂N₄O₄S
Purity:99.91%
Color and Shape:Solid
Molecular weight:508.63
Ref: TM-T16111
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Sulpiride
CAS:
- 15676-16-1
Sulpiride (Aiglonyl) is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
Formula:C₁₅H₂₃N₃O₄S
Purity:99.94%
Color and Shape:White Crystalline Powder
Molecular weight:341.43
Ref: TM-T1201
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Pizotifen
CAS:
- 15574-96-6
Pizotifen is a serotonin antagonist with mild anticholinergic effects, used in migraine prevention. Not available in the USA.
Formula:C₁₉H₂₁NS
Purity:99.93%
Color and Shape:Solid
Molecular weight:295.44
Ref: TM-T1442
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Nylidrin hydrochloride
CAS:
- 849-55-8
Nylidrin HCl inhibits IgG1-induced histamine release in guinea pigs and IgE-induced release in rat mast cells & human basophils.
Formula:C₁₉H₂₆ClNO₂
Purity:99.35%
Color and Shape:Solid
Molecular weight:335.87
Ref: TM-T0173
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Betaxolol hydrochloride
CAS:
- 63659-19-8
Betaxolol HCl (SL 75212) is a cardioselective beta-blocker for hypertension without reported liver injury.
Formula:C₁₈H₃₀ClNO₃
Purity:99.48% - 99.56%
Color and Shape:Solid
Molecular weight:343.89
Ref: TM-T0226
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Dopexamine hydrochloride
CAS:
- 86484-91-5
Dopexamine hydrochloride (FPL60278AR) is a β2-adrenoceptor agonist that modulates inflammation and protects organs without affecting hemodynamics.
Formula:C₂₂H₃₄Cl₂N₂O₂
Purity:98.55%
Color and Shape:Solid
Molecular weight:429.42
Ref: TM-T11318
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Pizotifen Malate
CAS:
- 5189-11-7
Pizotifen Malate (BC-105 malate), a highly selective 5-HT receptor blocking agent, is a drug based on benzocycloheptane.
Formula:C₁₉H₂₁NS·C₄H₆O₅
Purity:>99.99%
Color and Shape:Solid
Molecular weight:429.53
Ref: TM-T0225
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Spiperone
CAS:
- 749-02-0
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds.
Formula:C₂₃H₂₆FN₃O₂
Purity:99.34% - 99.91%
Color and Shape:Solid
Molecular weight:395.47
Ref: TM-T0280
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CE3F4
CAS:
- 143703-25-7
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).
Formula:C₁₁H₁₀Br₂FNO
Purity:97.15% - 98.06%
Color and Shape:Solid
Molecular weight:351.01
Ref: TM-T12616L
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2-Bromo-6-methoxynaphthalene
CAS:
- 5111-65-9
2-Bromo-6-methoxynaphthalene was used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.
Formula:C₁₁H₉BrO
Purity:98.51%
Color and Shape:White To Off-White Powder
Molecular weight:237.09
Ref: TM-T0663
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Ketanserin
CAS:
- 74050-98-9
Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.
Formula:C₂₂H₂₂FN₃O₃
Purity:99.19% - 99.73%
Color and Shape:Solid
Molecular weight:395.43
Ref: TM-T1066
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Prucalopride
CAS:
- 179474-81-8
Prucalopride (R-93877), a selective 5-HT4A/4B agonist (Ki: 2.5/8 nM), is >290x more specific for these receptors.
Formula:C₁₈H₂₆ClN₃O₃
Purity:>99.99%
Color and Shape:Solid
Molecular weight:367.87
Ref: TM-T2542
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CD80-IN-3
CAS:
- 486449-65-4
CD80-IN-3 is a potent CD80 inhibitor and inhibits CD80/CD28 interaction (Kd: 125 nM; EC50: 630 nM).
Formula:C₁₇H₁₀FN₃O₃
Purity:98.08%
Color and Shape:Solid
Molecular weight:323.28
Ref: TM-T10722
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Venlafaxine hydrochloride
CAS:
- 99300-78-4
Venlafaxine HCl, a cyclohexanol phenethylamine, acts as an SNRI antidepressant.
Formula:C₁₇H₂₈ClNO₂
Purity:97.32% - 99.86%
Color and Shape:White Crystalline Powder
Molecular weight:313.86
Ref: TM-T0472
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Alfuzosin hydrochloride
CAS:
- 81403-68-1
Alfuzosin hydrochloride (Alfuzosin HCl) is an α1 adrenergic receptor antagonist. It applies to treat benign prostatic hyperplasia (BPH).
Formula:C₁₉H₂₇N₅O₄·HCl
Purity:99.78%
Color and Shape:White To Off-White Solid
Molecular weight:425.91
Ref: TM-T0091
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Chlorprothixene hydrochloride
CAS:
- 6469-93-8
Chlorprothixene hydrochloride, a typical antipsychotic, blocks 5-HT2, D1-D3, H1, muscarinic, and alpha1 receptors.
Formula:C₁₈H₁₈ClNS·HCl
Purity:99.76%
Color and Shape:White Powder
Molecular weight:352.32
Ref: TM-T0074L
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Tegaserod maleate
CAS:
- 189188-57-6
Tegaserod (SDZ-HTF-919), a 5-HT4 agonist for irritable bowel syndrome, was withdrawn by FDA on March 30, 2007, due to heart risk concerns.
Formula:C₂₀H₂₇N₅O₅
Purity:98% - 99.06%
Color and Shape:White Powder
Molecular weight:417.46
Ref: TM-T1551
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Talastine
CAS:
- 16188-61-7
Talastine is an antihistamine compound that can induce an allergic rash.
Formula:C₁₉H₂₁N₃O
Purity:98.50% - 99.44%
Color and Shape:Solid
Molecular weight:307.39
Ref: TM-T68150
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CP-809101 hydrochloride
CAS:
- 1215721-40-6
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
Formula:C₁₅H₁₈Cl₂N₄O
Purity:99.5%
Color and Shape:Solid
Molecular weight:341.24
Ref: TM-T10871
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Methyldopa
CAS:
- 555-30-6
Methyldopa (MK-351), an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or
Formula:C₁₀H₁₃NO₄
Purity:98.95% - 99.86%
Color and Shape:Less Or Almost Colorless Crystals Or White To Yellowish-White Fine
Molecular weight:211.21
Ref: TM-T0505
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Quetiapine
CAS:
- 111974-69-7
Quetiapine treats schizophrenia and bipolar I, targeting serotonin, dopamine, and adrenoreceptor subtypes, plus H1 histamine receptor.
Formula:C₂₁H₂₅N₃O₂S
Purity:99.14% - 99.63%
Color and Shape:White To Off-White Crystalline Powder
Molecular weight:383.51
Ref: TM-T0162
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Vapreotide acetate
CAS:
- 849479-74-9
Vapreotide acetate (BMY-41606 acetate) is an antagonist of the neurokinin-1 (NK1) receptor (IC50: 330 nM).
Formula:C₅₉H₇₄N₁₂O₁₁S₂
Purity:99.89%
Color and Shape:Solid
Molecular weight:1191.42
Ref: TM-T13306L
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Amiselimod hydrochloride
CAS:
- 942398-84-7
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
Formula:C₁₉H₃₁ClF₃NO₃
Purity:99.55%
Color and Shape:Solid
Molecular weight:413.9
Ref: TM-T10305
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Alverine citrate
CAS:
- 5560-59-8
Alverine citrate (NSC 35459) is utilized in functional gastrointestinal disorders.
Formula:C₂₆H₃₅NO₇
Purity:98.53% - 99.43%
Color and Shape:Coa
Molecular weight:473.57
Ref: TM-T0428
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Roluperidone
CAS:
- 359625-79-9
Roluperidone (CYR-101) is a novel cyclic amide derivative.
Formula:C₂₂H₂₃FN₂O₂
Purity:96.46% - 97.77%
Color and Shape:Solid
Molecular weight:366.43
Ref: TM-T15034
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Filorexant
CAS:
- 1088991-73-4
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
Formula:C₂₄H₂₅FN₄O₂
Purity:98.88%
Color and Shape:Solid
Molecular weight:420.48
Ref: TM-T16096
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Terfenadine
CAS:
- 50679-08-8
Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.
Formula:C₃₂H₄₁NO₂
Purity:98.76% - 99.75%
Color and Shape:Solid
Molecular weight:471.67
Ref: TM-T1266
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Clonidine hydrochloride
CAS:
- 4205-91-8
Clonidine hydrochloride (Catapres) is a centrally active α-adrenergic agonist used predominantly as an antihypertensive agent.
Formula:C₉H₁₀Cl₃N₃
Purity:99.16% - 99.86%
Color and Shape:Solid
Molecular weight:266.55
Ref: TM-T1247
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Tropisetron hydrochloride
CAS:
- 105826-92-4
Tropisetron hydrochloride (Tropisetron HCl) is a selective, competitive serotonin 5-HT3 receptor antagonist, with antinauseant and antiemetic activities.
Formula:C₁₇H₂₁ClN₂O₂
Purity:99.72% - 99.83%
Color and Shape:Solid
Molecular weight:320.82
Ref: TM-T1173