DNA Damage/DNA Repair
DNA damage/DNA repair inhibitors are compounds that interfere with the processes involved in detecting and repairing DNA damage. These inhibitors are critical for studying the mechanisms of genomic stability, mutagenesis, and the response to DNA damage. They are also important in cancer research, as many tumors rely on specific DNA repair pathways for survival. By inhibiting these pathways, DNA damage/DNA repair inhibitors can enhance the effectiveness of chemotherapy and radiation therapy. At CymitQuimica, we provide a diverse range of high-quality DNA damage/DNA repair inhibitors to support your research in molecular biology, oncology, and pharmacology.
Subcategories of "DNA Damage/DNA Repair"
- ATM/ATR(71 products)
- DNA Alkylation(11 products)
- DNA Methyltransferase(421 products)
- DNA gyrase(11 products)
- DNA-PK(51 products)
- MTH1(1 products)
- Nucleoside Antimetabolite/Analog(1,388 products)
- Reverse Transcriptase(43 products)
- Sirtuin(88 products)
- Telomerase(33 products)
- Topoisomerase(136 products)
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Found 958 products of "DNA Damage/DNA Repair"
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Zidovudine
CAS:<p>Zidovudine, a synthetic dideoxynucleoside, blocks DNA replication by inhibiting DNA polymerase after activation.</p>Formula:C10H13N5O4Purity:99.84% - 99.91%Color and Shape:White To Off-White CrystalsMolecular weight:267.24Gimeracil
CAS:<p>Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.</p>Formula:C5H4ClNO2Purity:99.80%Color and Shape:SolidMolecular weight:145.54Carboplatin
CAS:<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Adenine
CAS:<p>Adenine: a purine nucleobase vital for ATP, NAD, FAD production, and DNA/RNA synthesis.</p>Formula:C5H5N5Purity:99.39% - 99.95%Color and Shape:SolidMolecular weight:135.13Moxifloxacin hydrochloride
CAS:<p>Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.</p>Formula:C21H25ClFN3O4Purity:99.91% - >99.99%Color and Shape:SolidMolecular weight:437.89Balofloxacin
CAS:<p>Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.</p>Formula:C20H24FN3O4Purity:99.62% - 99.98%Color and Shape:Crystalline SolidMolecular weight:389.42Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formula:C37H48F2N5O11PPurity:99.79%Color and Shape:SolidMolecular weight:807.77Gemfibrozil
CAS:<p>Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.</p>Formula:C15H22O3Purity:99.53% - 99.88%Color and Shape:Crystals From Hexane SolidMolecular weight:250.33Enoxacin
CAS:<p>Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.</p>Formula:C15H17FN4O3Purity:98.68% - 99.89%Color and Shape:Off-White To Yellow CrystalsMolecular weight:320.32GED-0507-34 Levo
CAS:<p>GED-0507-34 Levo,(S)-3-(4-Aminophenyl)-2-methoxypropanoic acid,an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis.</p>Formula:C10H13NO3Purity:98.19%Color and Shape:SolidMolecular weight:195.22Nalidixic acid
CAS:<p>Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.</p>Formula:C12H12N2O3Purity:99.9% - 99.95%Color and Shape:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Molecular weight:232.24Chlorambucil
CAS:<p>Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.</p>Formula:C14H19Cl2NO2Purity:97.37% - 98.45%Color and Shape:Off-White Slightly Granular Powder Melting Point 65-69°CMolecular weight:304.21LTURM34
CAS:<p>LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.</p>Formula:C24H18N2O3SPurity:99.34%Color and Shape:SolidMolecular weight:414.48STL127705
CAS:<p>STL127705 inhibits Ku 70/80 protein & DNA-PKCS kinase, IC50s: 3.5 μM & 2.5 μM.</p>Formula:C22H20FN5O4Purity:99.53% - 99.81%Color and Shape:SolidMolecular weight:437.42Levofloxacin hydrate
CAS:<p>Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H20FN3O4H2OPurity:98.26%Color and Shape:Pale Yellow SolidMolecular weight:370.38SIRT-IN-2
CAS:<p>SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).</p>Formula:C15H21N5O3S2Purity:98.26%Color and Shape:SolidMolecular weight:383.49Niraparib (R-enantiomer)
CAS:<p>Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).</p>Formula:C19H20N4OPurity:99.83%Color and Shape:SolidMolecular weight:320.39Hydroxychloroquine sulfate
CAS:<p>Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase.</p>Formula:C18H26ClN3O·H2SO4Purity:98.92% - 99.88%Color and Shape:Odorless SolidMolecular weight:433.95NTP42
CAS:<p>NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)</p>Formula:C25H23F2N3O5SPurity:97.55%Color and Shape:SolidMolecular weight:515.53Norfloxacin
CAS:<p>Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.</p>Formula:C16H18FN3O3Purity:98.54% - 99.83%Color and Shape:White To Light-Yellow Crystalline Powder SolidMolecular weight:319.33Ciprofloxacin monohydrochloride
CAS:<p>Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.</p>Formula:C17H18FN3O3·HClPurity:99.5% - >99.99%Color and Shape:White Or Light Yellow Crystalline PowderMolecular weight:367.80MSDC-0602K
CAS:<p>MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.</p>Formula:C19H16KNO5SPurity:99.42%Color and Shape:SolidMolecular weight:409.5Lomefloxacin
CAS:<p>Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.</p>Formula:C17H19F2N3O3Purity:98.59%Color and Shape:Off-White To Yellow CrystalsMolecular weight:351.35Tallimustine HCl
CAS:<p>Tallimustine HCl, an AT-specific alkylating agent, treats leukemia in immunodeficiency mouse models.</p>Formula:C32H39Cl3N10O4Purity:98.52%Color and Shape:SoildMolecular weight:734.08Ofloxacin
CAS:<p>Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic.</p>Formula:C18H20FN3O4Purity:99.33% - 99.87%Color and Shape:Off-White SolidMolecular weight:361.37LY518674
CAS:<p>LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.</p>Formula:C23H27N3O4Purity:98.87%Color and Shape:SolidMolecular weight:409.48Decitabine
CAS:<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Formula:C8H12N4O4Purity:98.06% - 99.87%Color and Shape:Physical Description Fine White Crystalline Powder Used As A DrugMolecular weight:228.21YPX-C-05
CAS:<p>YPX-C-05, an isohydroxamic acid derivative, is an HDAC inhibitor with vasodilatory and antihypertensive activity.CAS 번호134608-84-5</p>Formula:C21H19N3O4Purity:98.09%Color and Shape:SoildMolecular weight:377.39FEN1-IN-1
CAS:<p>FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.</p>Formula:C15H12N2O5SPurity:99.65% - 99.80%Color and Shape:SolidMolecular weight:332.33Fleroxacin
CAS:<p>Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone. It strongly inhibits the DNA-supercoiling activity of DNA gyrase.</p>Formula:C17H18F3N3O3Purity:99.58% - 99.79%Color and Shape:White Needle-Like CrystalsMolecular weight:369.34Lurtotecan
CAS:<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formula:C28H30N4O6Purity:99.18%Color and Shape:SoildMolecular weight:518.56Ganciclovir
CAS:<p>Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.</p>Formula:C9H13N5O4Purity:99.55% - 99.58%Color and Shape:White PowderMolecular weight:255.23Ledoxantrone trihydrochloride
CAS:<p>Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the study of digestive disorders and urologic disorders.</p>Formula:C21H30Cl3N5OSPurity:98.13%Color and Shape:SoildMolecular weight:506.92Abexinostat
CAS:<p>Abexinostat (PCI-24781) is a pan-HDAC inhibitor, strongest on HDAC1; less so on HDACs 2, 3, 6, 10. Very select for HDAC8. In Phase 1/2 trials.</p>Formula:C21H23N3O5Purity:98.19% - 98.43%Color and Shape:SolidMolecular weight:397.42CG347B
CAS:<p>CG347B is a selective inhibitor of HDAC6.</p>Formula:C16H17N3O2Purity:98.34%Color and Shape:SolidMolecular weight:283.33Procarbazine hydrochloride
CAS:<p>Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities.</p>Formula:C12H19N3O·HClPurity:96.99% - ≥98%Color and Shape:(Ntp 1992)Molecular weight:257.76Dithranol
CAS:<p>Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially</p>Formula:C14H10O3Purity:93.49% - 99.33%Color and Shape:Physical Description Lemon Yellow Leaflets Or Plates Or An Orange Powder MeltingMolecular weight:226.23Ciprofloxacin
CAS:<p>Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!</p>Formula:C17H18FN3O3Purity:98.77% - 99.91%Color and Shape:White PowderMolecular weight:331.34Elimusertib hydrochloride(1876467-74-1 free base)
<p>Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor</p>Formula:C20H22ClN7OPurity:98.8% - 99.03%Color and Shape:SolidMolecular weight:411.89NSC 31150
CAS:<p>Indomethacin sodium hydrate (Indometacin sodium hydrate) is a COX1/2 inhibitor that induces migraine headaches and may be used in studies of rheumatoid joints.</p>Formula:C10H5Cl2NO2SPurity:98.07%Color and Shape:SolidMolecular weight:274.125-Azacytidine
CAS:<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Formula:C8H12N4O5Purity:99.31% - 99.79%Color and Shape:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Molecular weight:244.2XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formula:C23H25ClN4O2Purity:98.52%Color and Shape:SoildMolecular weight:424.92Levetiracetam
CAS:<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Formula:C8H14N2O2Purity:99.67% - 99.86%Color and Shape:White Crystalline PowderMolecular weight:170.21Abacavir
CAS:<p>Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine.</p>Formula:C14H18N6OPurity:99.36% - 99.81%Color and Shape:White PowderMolecular weight:286.33Telomerase-IN-2
CAS:<p>Telomerase-IN-2 (Telomerase inhibitor 2) shows potent inhibitory activity against telomerase by decreasing the expression of dyskerin (IC50: 0.89 µM).</p>Formula:C34H39N3O9Purity:99.32%Color and Shape:SolidMolecular weight:633.69Nalidixic acid sodium salt
CAS:<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formula:C12H11N2NaO3Purity:99.72% - 99.95%Color and Shape:White To Off-White PowderMolecular weight:254.22Topixantrone 2HCl
CAS:<p>Topixantrone 2HCl is a DNA topoisomerase inhibitor with antitumor activity for the study of gastric and prostate cancer.</p>Formula:C21H28Cl2N6O2Purity:99.96% - >99.99%Color and Shape:SoildMolecular weight:467.391-Naphthohydroxamic acid
CAS:<p>1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1</p>Formula:C11H9NO2Purity:99.19%Color and Shape:SolidMolecular weight:187.19Mifobate
CAS:Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。Formula:C11H17ClO7P2Purity:99.12%Color and Shape:SolidMolecular weight:358.65Clofibric acid
CAS:<p>Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.</p>Formula:C10H11ClO3Purity:99.47% - 99.8%Color and Shape:Pale Yellow SolidMolecular weight:214.65AES-135
CAS:<p>AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.</p>Formula:C33H29F6N3O5SPurity:97.72%Color and Shape:SolidMolecular weight:693.66Teniposide
CAS:<p>Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and</p>Formula:C32H32O13SPurity:97.7% - 99.45%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:656.65Gatifloxacin
CAS:<p>Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.</p>Formula:C19H22FN3O4Purity:99.50% - 99.85%Color and Shape:White PowderMolecular weight:375.39Sparfloxacin
CAS:<p>Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription.</p>Formula:C19H22F2N4O3Purity:99.67% - >99.99%Color and Shape:Light Yellow PowderMolecular weight:392.40Altretamine
CAS:<p>Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.</p>Formula:C9H18N6Purity:99.54%Color and Shape:Less Crystalline Solid Insoluble In Water (Ntp 1992) Physical Description Colorless Crystalline Solid Insoluble In Water (Ntp 1992)Molecular weight:210.28MC3482
CAS:<p>MC3482 is a specific inhibitor of sirtuin5 (SIRT5).</p>Formula:C33H38N4O8Purity:98% - 99.90%Color and Shape:SoildMolecular weight:618.68G150
CAS:<p>G150 suppresses DSDNA-induced interferon; IC50: 10.2 nM. It's a potent, selective H-CGAS inhibitor.</p>Formula:C18H16Cl2N4O2Purity:97.75%Color and Shape:SolidMolecular weight:391.25Flumequine
CAS:<p>Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.</p>Formula:C14H12FNO3Purity:98.92% - 99.4%Color and Shape:White Crystalline Powder SolidMolecular weight:261.25Pefloxacin Mesylate
CAS:<p>Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-</p>Formula:C18H24FN3O6SPurity:99.86%Color and Shape:SolidMolecular weight:429.46Foscarnet sodium
CAS:<p>Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis.</p>Formula:CNa3O5PPurity:98.52%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:191.95Acyclovir
CAS:<p>Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2,</p>Formula:C8H11N5O3Purity:99.77% - >99.99%Color and Shape:Crystals From Methanol SolidMolecular weight:225.2Ceramides Mixture
CAS:<p>Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.</p>Formula:C36H71NO4Purity:98%Color and Shape:SolidMolecular weight:581.967Candesartan
CAS:<p>Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.</p>Formula:C24H20N6O3Purity:98.3% - 99.55%Color and Shape:Colorless Solid CrystallineMolecular weight:440.47Bendamustine hydrochloride
CAS:<p>Bendamustine hydrochloride (EP-3101) (IC50 of 50 μM) is an alkylating agent associated with DNA damage.</p>Formula:C16H21Cl2N3O2·HClPurity:97.71%Color and Shape:SolidMolecular weight:394.72RBN-2397
CAS:<p>RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.</p>Formula:C20H23F6N7O3Purity:98.48% - 99.8%Color and Shape:SolidMolecular weight:523.43HDAC-IN-40
CAS:<p>HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects</p>Formula:C15H22N2O6Purity:99.04%Color and Shape:SoildMolecular weight:326.35Ifosfamide
CAS:<p>Ifosfamide (NSC-109724), a prodrug, is a cyclophosphamide analog with antineoplastic action by DNA alkylation and crosslinking.</p>Formula:C7H15Cl2N2O2PPurity:99.86% - ≥95%Color and Shape:SolidMolecular weight:261.09Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Formula:C9H16N4O7Purity:>99.99%Color and Shape:SolidMolecular weight:292.25DRF-1042 HCl
<p>DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.</p>Formula:C22H21ClN2O6Purity:97.93%Color and Shape:SolidMolecular weight:444.87Cetaben
CAS:<p>Cetaben, a non-fibrotic drug, lowers cholesterol and triglycerides without PPARα activation.</p>Formula:C23H39NO2Purity:99.59%Color and Shape:SolidMolecular weight:361.56Methotrexate
CAS:<p>Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.</p>Formula:C20H22N8O5Purity:96.84% - 99.91%Color and Shape:Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna SynthesisMolecular weight:454.44Cisplatin
CAS:<p>Cisplatin (CDDP) is a DNA cross-linking agent.</p>Formula:Cl2H6N2PtPurity:97.13% - 99.63%Color and Shape:Orange-Yellow To Deep Yellow Solid Or PowderMolecular weight:300.04BRD 4354
CAS:<p>BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.</p>Formula:C21H23ClN4OPurity:99.86%Color and Shape:SolidMolecular weight:382.89Thio-TEPA
CAS:<p>Thio-TEPA (Tiofosyl) is a polyfunctional, organophosphorus alkylating agent with antineoplastic activity.</p>Formula:C6H12N3PSPurity:98.45% - 99.07%Color and Shape:White Crystals Or PowderMolecular weight:189.22DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Formula:C25H25N3OPurity:98.95%Color and Shape:SolidMolecular weight:383.49Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formula:C15H17FN4O3H2OPurity:99.50%Color and Shape:SolidMolecular weight:347.34Ramatroban
CAS:<p>Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.</p>Formula:C21H21FN2O4SPurity:98.75% - >99.99%Color and Shape:Crystalline SolidMolecular weight:416.47HDAC6-IN-50
<p>HDAC6-IN-50 (Compound 4) is an effective inhibitor of HDAC6 with an IC50 value of 35 nM. It is utilized in the study of Parkinson's disease (PD) and Alzheimer's disease (AD).</p>Color and Shape:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:<p>3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.</p>Formula:C20H15N3O2SPurity:99.32%Color and Shape:SolidMolecular weight:361.42(±)4-HDHA
CAS:<p>(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.</p>Formula:C22H32O3Purity:97.97%Color and Shape:SolidMolecular weight:344.49HDAC9-IN-1
<p>HDAC9-IN-1 (Compound 7g) is a potent inhibitor of HDAC9, exhibiting an IC50 of 40 nM. This compound effectively suppresses various human cancer cell lines, induces apoptosis, modulates caspase-related proteins and p38, and results in DNA damage.</p>Formula:C27H22N4O3SColor and Shape:SolidMolecular weight:482.55SIRT2-IN-16
<p>SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).</p>Formula:C55H91N9O15SColor and Shape:SolidMolecular weight:1150.43Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Color and Shape:Odour SolidNHC-diphosphate triammonium
<p>NHC-triphosphate triammonium is a phosphorylated metabolite of NHC, incorporated into HCV RNA by viral polymerase.</p>Color and Shape:SolidCA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80BML-278
CAS:<p>BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and</p>Formula:C24H25NO4Purity:99.53%Color and Shape:SolidMolecular weight:391.46ACT-387042
CAS:<p>ACT-387042 is a Bacterial Topoisomerase Inhibitor, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.</p>Formula:C23H26FN5O4SColor and Shape:SolidMolecular weight:487.55GW 1929 hydrochloride
CAS:<p>Oral PPARγ agonist with pEC50 of 8.05; low affinity for PPARα, PPARδ. Reduces blood glucose, fatty acids, triglycerides in vivo.</p>Formula:C30H30ClN3O4Color and Shape:SolidMolecular weight:532.04PB200
<p>PB200, an HDAC6 inhibitor, demonstrates significant antidepressant effects with an IC50 value of 1.97 nM. It operates by normalizing aberrant HDAC6 expression levels and alleviating neuroinflammation.</p>Formula:C17H18FN3O2Color and Shape:SolidMolecular weight:315.34Topoisomerase II inhibitor 13
CAS:<p>WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.</p>Formula:C22H23N9Purity:98.4%Color and Shape:SoildMolecular weight:413.48Tertomotide hydrochloride
CAS:<p>Tertomotide (GV1001) hydrochloride is a peptide vaccine composed of a 16-amino acid sequence from human telomerase reverse transcriptase (hTERT). It exhibits neuroprotective properties and has potential for research in Alzheimer's disease.</p>Formula:C85H147ClN26O21Color and Shape:SolidMolecular weight:1904.69Murrayanol
<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>Formula:C24H29NO2Color and Shape:SolidMolecular weight:363.501Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414WAY-323061
CAS:<p>WAY-323061 is a SIRT2 inhibitor.</p>Formula:C25H21N5O2SPurity:99.33%Color and Shape:SolidMolecular weight:455.53Melphalan
CAS:<p>Melphalan is an alkylating agent. It has been used in combination with the HDAC inhibitor as a drug for the treatment of multiple myeloma (MM) cell lines and as a chemotherapy agent for breast cancer cell lines.</p>Formula:C13H18Cl2N2O2Molecular weight:305.219-Nitrooleate
CAS:<p>Nitrated fatty acids like nitrolinoleate and nitrooleate serve as PPARγ ligands and release NO; found in plasma, they aid adipocyte differentiation.</p>Formula:C18H33NO4Color and Shape:SolidMolecular weight:327.465AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94Ketopioglitazone
CAS:<p>Ketopioglitazone is an active metabolite of pioglitazone.</p>Formula:C19H18N2O4SColor and Shape:SolidMolecular weight:370.42FKB04
<p>FKB04 is a telomeric repeat binding factor 2 (TRF2) inhibitor that exerts its antitumor activity by disrupting the telomere maintenance mechanisms in hepatocellular carcinoma cells. This leads to T-loop defects, inducing telomere shortening and cellular senescence. Additionally, FKB04 inhibits tumor growth in a human liver cancer xenograft mouse model (by implanting Huh-7 cells in BALB/c mice). This compound is utilized in research focused on liver cancer.</p>Color and Shape:Odour Solid(±)4(5)-DiHDPA lactone
CAS:<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Formula:C22H32O3Color and Shape:SolidMolecular weight:344.495Heliotrine N-oxide
CAS:<p>Heliotrine N-oxide, a PA N-oxide, triggers pyrrolic DNA adducts and may cause liver tumors.</p>Formula:C16H27NO6Color and Shape:SolidMolecular weight:329.393PNU-142586
CAS:<p>PNU-142586 is a bio-active chemical.</p>Formula:C16H20FN3O6Color and Shape:SolidMolecular weight:369.34Elomotecan hydrochloride
CAS:<p>Elomotecan hydrochloride (BN 80927), a potent hCPT analog, inhibits topoisomerases I/II, outperforming other anticancer drugs.</p>Formula:C29H33Cl2N3O4Color and Shape:SolidMolecular weight:558.51-Stearoyl-2-docosahexaenoyl-sn-glycero-3-PC
CAS:<p>Phospholipid with stearic and docosahexaenoic acids used in membrane studies; decreases in ALS mouse model.</p>Formula:C48H84NO8PColor and Shape:SolidMolecular weight:834.16Elinafide
CAS:<p>Elinafide, a dinaphthylimide cytotoxic agent, is a DNA-targeted anticancer agent that has shown antitumor activity in in vitro and in vivo assays.</p>Formula:C31H28N4O4Purity:97.29%Color and Shape:SolidMolecular weight:520.58Topoisomerase I/II inhibitor 5
<p>TopoisomeraseI/II inhibitor 5 (compound 1) stabilizes G4 structures through binding and concurrently inhibits the relaxation activities of TopoI and II.</p>Color and Shape:Odour SolidHippeastrine
CAS:<p>Hippeastrine is an alkaloid that inhibits Top I dose-dependently with a 7.25 μg/mL IC50 and has anticancer properties.</p>Formula:C17H17NO5Color and Shape:SolidMolecular weight:315.32Multi-target kinase inhibitor 4
<p>Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and a potent chemosensitizer that enhances the number of DNA double-strand breaks induced by Doxorubicin. It serves as an effective multidrug resistance (MDR) inhibitor, demonstrating inhibitory activity against P-glycoprotein (P-gp) mediated drug efflux. Multi-target kinase inhibitor 4 can be encapsulated in PEG-coated lipid nanoparticles.</p>Color and Shape:Odour SolidDNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidCP 84364
CAS:<p>CP 84364 is a metabolite of CP-80794.</p>Formula:C14H18N2O4Color and Shape:SolidMolecular weight:278.30Diflomotecan
CAS:<p>Diflomotecan (BN 80915) is a strong oral topoisomerase I inhibitor with high plasma stability and significant preclinical anti-cancer efficacy.</p>Formula:C21H16F2N2O4Color and Shape:SolidMolecular weight:398.36CUDA disodium
<p>CUDA disodium is an effective, soluble epoxide hydrolase (sEH) inhibitor, with IC50 values of 11.1 nM for murine sEH and 112 nM for human sEH. It selectively enhances the activity of peroxisome proliferator-activated receptor PPARalpha. CUDA disodium may be valuable for cardiovascular disease research.</p>Color and Shape:Odour Solid1-Methyladenosine-d3
<p>1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium-labeled 1-Methyladenosine. This compound is a modification of RNA that serves as a biomarker for tumors, with elevated levels in the body linked to cancer development. Upon methylation, 1-Methyladenosine upregulates the expression of PPARδ, regulates cholesterol metabolism, and activates the Hedgehog signaling pathway, thereby driving the onset of liver tumors.</p>Color and Shape:Odour SolidMST-312
CAS:<p>MST-312, a telomerase inhibitor derived from green tea's EGCG, has research potential in cancer, including MM.</p>Formula:C20H16N2O6Purity:99.61% - 99.68%Color and Shape:SolidMolecular weight:380.35DST Crosslinker
CAS:<p>DST is a cleavable, bifunctional crosslinker; it doesn't disrupt protein disulfides, breaks with oxidizers.</p>Formula:C12H12N2O10Color and Shape:SolidMolecular weight:344.232Banoxantrone-d12 dihydrochloride
CAS:<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48SpCas9 D10A Nickase
<p>SpCas9 D10A Nickase is a variant of the Cas9 protein. This mutation retains the functionality of one cleavage domain of the Cas9 nuclease, allowing it to specifically nick a target single strand. Additionally, SpCas9 D10A Nickase is effective in reducing off-target effects.</p>Anticancer agent 177
<p>Anticanceragent 177 (Compound 11b) is an NAMPT inhibitor and DNA alkylating agent with antitumor activity both in vitro and in vivo.</p>Formula:C28H36Cl2N4O2Molecular weight:530.22153Corydamine
<p>Corydamine is a useful organic compound for research related to life sciences and the catalog number is T124768.</p>Formula:C20H18N2O4Color and Shape:SolidMolecular weight:350.374DB1255 2TFA
<p>DB1255 2TFA is an ERG/DNA binding inhibitor with an unusual and potent monomer binding pattern at the minor groove site for the study of genetic disorders.</p>Formula:C26H20F6N4O4S2Purity:98.32%Color and Shape:SolidMolecular weight:630.58Dichlorogelignate
CAS:<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formula:C32H34O18Color and Shape:SolidMolecular weight:706.6Cytidine 5'-diphosphate trisodium salt
CAS:<p>CDP, a trisodium salt, helps synthesize DNA/RNA by aiding phosphoryl transfer from ATP to CMP via UMPK.</p>Formula:C9H15N3Na3O11P2Purity:99.55%Color and Shape:White Crystalline PowderMolecular weight:472.15PDPH Crosslinker
CAS:<p>PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker.</p>Formula:C8H11N3OS2Color and Shape:SolidMolecular weight:229.32HDAC-IN-52
CAS:<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Formula:C24H20N4O2Purity:99.47%Color and Shape:SolidMolecular weight:396.44TRF1-TIN2 interaction-IN-1
<p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>Formula:C19H18O6SColor and Shape:SolidMolecular weight:374.4115-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Color and Shape:Odour Solid20-carboxy Arachidonic Acid
CAS:<p>20-COOH-AA, 20-HETE metabolite, inhibits kidney ion transport, relaxes constricted vessels, and activates PPARα/γ.</p>Formula:C20H30O4Color and Shape:SolidMolecular weight:334.456Amorfrutin B
CAS:<p>Amorfrutin B is a useful organic compound for research related to life sciences. The catalog number is T124211 and the CAS number is 78916-42-4.</p>Formula:C26H32O4Color and Shape:SolidMolecular weight:408.538ABP/PPAR modulator 1
<p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>Formula:C33H39NO7Color and Shape:SolidMolecular weight:561.67Gimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>AsCas12a Nuclease
<p>AsCas12a Nuclease is a CRISPR nuclease capable of specifically cleaving double-stranded DNA. It is used in gene editing research.</p>25-Hydroxytachysterol3
CAS:<p>25-Hydroxytachysterol3 is a metabolite of Vitamin D3 that inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts while promoting the differentiation of keratinocytes and the expression of antioxidant-related genes. It activates receptors including the vitamin D receptor (VDR), aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXRα/β), and peroxisome proliferator-activated receptor γ (PPARγ), and enhances the expression of CYP24A1.</p>Formula:C27H44O2Color and Shape:SolidMolecular weight:400.64MPT0B390
CAS:<p>MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.</p>Formula:C17H17N3O5SPurity:99.4%Color and Shape:SolidMolecular weight:375.4NHC-diphosphate
CAS:<p>NHC-diphosphate, a phosphorylated β-d-N4-Hydroxycytidine metabolite, is a potent antiviral against VEEV, CHIKV, and HCV.</p>Formula:C9H15N3O12P2Color and Shape:SolidMolecular weight:419.18nTZDpa
CAS:<p>nTZDpa is an antibiotic with antimicrobial activity.</p>Formula:C22H15Cl2NO2SColor and Shape:SolidMolecular weight:428.33Abd110
CAS:<p>Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].</p>Formula:C41H42N8O7SColor and Shape:SolidMolecular weight:790.89Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formula:C23H20N2O5Purity:98.35%Color and Shape:SoildMolecular weight:404.42Pericosine A
CAS:<p>Pericosine A, a fungal metabolite from P. byssoides, shows anticancer effects (GI50s = 0.05-24.55 μM) and EGFR inhibition (40-70% at 100 μg/ml).</p>Formula:C8H11ClO5Color and Shape:SolidMolecular weight:222.62N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS:<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.661(iso)-BRD20322
CAS:<p>(iso)-BRD20322 is an isomer of BRD20322, a novel potent inhibitor of spCas9，disrupts the binding of spCas9 to DNA and reduces non-specific DNA editing events.</p>Formula:C27H31N3O2Purity:99.60% - 99.60%Color and Shape:SoildMolecular weight:429.5517-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Formula:C22H30O3Color and Shape:SolidMolecular weight:342.479MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Color and Shape:Odour SolidHDAC1/6-IN-2
<p>HDAC1/6-IN-2 (I-c4), a dual inhibitor of HDAC1 and HDAC6, exhibits potent activity with IC50 values of 3.1 nM for HDAC1 and 2.95 nM for HDAC6. This compound demonstrates notable antitumor activity.</p>Formula:C22H17FN4O3Color and Shape:SolidMolecular weight:404.39NHC-triphosphate tetrasodium
<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>Formula:C9H12N3Na4O15P3Color and Shape:SolidMolecular weight:587.08Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55Mca-VDQVDGW-Lys(Dnp)-NH2
<p>Mca-VDQVDGW-Lys(Dnp)-NH2, a fluorogenic substrate specific to caspase-7, facilitates the quantification of caspase-7 activity.</p>Formula:C60H74N14O21Color and Shape:SolidMolecular weight:1327.31Antitumor agent-63
CAS:<p>Compound 40, a non-toxic 20(S)-O-CPT glycoconjugate, is stable, with low Topo I inhibition.</p>Formula:C38H46N4O18Color and Shape:SolidMolecular weight:846.79Berzosertib
CAS:<p>Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C24H25N5O3SPurity:97.34% - >99.99%Color and Shape:SolidMolecular weight:463.55Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Formula:C21H22N2O6Color and Shape:SolidMolecular weight:398.409Wistin
CAS:<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Formula:C23H24O10Color and Shape:SolidMolecular weight:460.43Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26Monascin
CAS:<p>Monascin: azaphilonoid in red-mold rice; anti-tumor and anti-inflammatory.</p>Formula:C21H26O5Purity:98%Color and Shape:SolidMolecular weight:358.43Nanaomycin A
CAS:<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Formula:C16H14O6Purity:98%Color and Shape:SolidMolecular weight:302.28VH 032 amide-PEG1-acid
CAS:<p>VHL ligand for PROTAC R&D; E3 ligase with PEG1 linker and carboxylic acid for target conjugation.</p>Formula:C28H38N4O7SColor and Shape:SolidMolecular weight:574.69SMPB Crosslinker
CAS:<p>SMPB crosslinker reacts with sulfhydryl/amino groups, has a longer chain than MBS, and a non-cleavable spacer arm.</p>Formula:C18H16N2O6Purity:98%Color and Shape:SolidMolecular weight:356.33Amrubicin
CAS:<p>The compound is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II.</p>Formula:C25H25NO9Purity:98%Color and Shape:SolidMolecular weight:483.47Silatecan
CAS:<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Formula:C26H30N2O5SiColor and Shape:SoildMolecular weight:478.61DMT-dG(ib) Phosphoramidite
CAS:<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Formula:C44H54N7O8PPurity:99.21%Color and Shape:SolidMolecular weight:839.92CHDI 00484077
CAS:<p>CHDI 00484077 is a highly selective, central nervous system (CNS) permeable Class IIa HDAC inhibitor, and can be used to study Huntington's disease.</p>Formula:C18H21F3N4O2Purity:99.26%Color and Shape:SolidMolecular weight:382.38ARN24139
<p>ARN24139: a topoisomerase II poison; IC50=7.3μM. Inhibits DU145, HeLa, A549 cell growth; IC50s=4.7, 3.8, 3.1μM.</p>Color and Shape:SolidSJ-106C
<p>SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.</p>Color and Shape:Odour SolidHDAC-IN-76
HDAC-IN-76 (compound 6i), a histone deacetylase (HDAC) inhibitor, demonstrates robust antimalarial activity, particularly against the asexual blood stages of Plasmodium. The compound exhibits potent efficacy with IC 50 values of 30 nM and 98 nM against Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine drug-resistant strain), respectively. Moreover, HDAC-IN-76 shows selective inhibition towards parasites, displaying IC 50 values of 7 nM and 9 nM against human HDAC1 and HDAC6, respectively, and effectively inhibits PfHDAC1.Formula:C27H26N4O4Color and Shape:SolidMolecular weight:470.52SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Formula:C22H24N2O9SColor and Shape:SolidMolecular weight:492.5Leriglitazone
CAS:<p>Leriglitazone, pioglitazone's metabolite, is a PPARγ agonist (Ki:1.2μM, EC50:680nM), enhancing transcription and stabilizing AF-2.</p>Formula:C19H20N2O4SPurity:98%Color and Shape:SolidMolecular weight:372.44Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Formula:C27H49NO5SPurity:>99.99% - >99.99%Color and Shape:SoildMolecular weight:499.75CAY10599
CAS:<p>CAY10599 has a wide range of applications in life science related research.</p>Formula:C38H41NO5Color and Shape:SolidMolecular weight:591.748STAT3/HDAC-IN-2
<p>STAT3/HDAC-IN-2 (compound 18), a dual inhibitor of STAT3 and HDAC, promotes autophagy and apoptosis. This compound features an amphiphilic hydroxamic acid hybrid structure, derived from the natural product isopropanol lactone (IAL), and functions as a nanoscale anticancer agent. It has the ability to self-assemble into nanoparticles in aqueous environments, leading to enhanced tumor tissue accumulation, increased cellular uptake, and improved anticancer efficacy compared to its free state.</p>Formula:C28H32N2O7Color and Shape:SolidMolecular weight:508.56CL2-MMT-SN38
CAS:<p>CL2-MMT-SN38 is a derivative of SN-38, which is a potent anticancer agent and the active metabolite of Irinotecan (CPT-11), a Topoisomerase I inhibitor.</p>Formula:C102H122N12O24Color and Shape:SolidMolecular weight:1900.15823-epi-26-Deoxyactein
CAS:<p>23-epi-26-Deoxyactein is a naturally occurring compound exhibiting anti-obesity and anti-cancer properties when administered orally [1] [2] [3].</p>Formula:C37H56O10Color and Shape:SolidMolecular weight:660.83CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.5117-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
CAS:<p>DPA metabolite 17-oxo-DPA, found in fish oil, spurs antioxidant genes, modulates inflammation, and activates PPARγ (EC50 ≈ 200 nM).</p>Formula:C22H32O3Color and Shape:SolidMolecular weight:344.49515-deoxy-Δ-12,14-Prostaglandin J2
CAS:<p>15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.</p>Formula:C20H28O3Purity:98%Color and Shape:Neat OilMolecular weight:316.43Top1/2-IN-1
<p>Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.</p>Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41Leriglitazone hydrochloride
CAS:<p>Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.</p>Formula:C19H21ClN2O4SColor and Shape:SolidMolecular weight:408.90SP4e
<p>SP4e is a PPAR-γ activator.SP4e was effective in decreasing blood glucose, total cholesterol, triglycerides and LDL levels and increasing HDL levels.</p>Formula:C22H17ClN2O2S2Purity:99.79%Color and Shape:SoildMolecular weight:440.97Topoisomerase IIα-IN-9
CAS:<p>Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Formula:C21H25NO6Purity:99.74%Color and Shape:SolidMolecular weight:387.43Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Formula:C50H56MgN2O8S2Purity:98.1%Color and Shape:SolidMolecular weight:901.43Elomotecan
CAS:<p>Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II.Cost-effective and quality-assured.</p>Formula:C29H32ClN3O4Color and Shape:SolidMolecular weight:522.04(R)-VX-984
CAS:<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Formula:C23H21D2N7OPurity:98%Color and Shape:SolidMolecular weight:415.49Prednimustine
CAS:<p>Prednimustine (Leo 1031; NSC 134087), an ester of Prednisolone and Chlorambucil, is used in leukemia and lymphoma studies.</p>Formula:C35H45Cl2NO6Color and Shape:SolidMolecular weight:646.64GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Formula:C20H29N3O7SPurity:99.97%Color and Shape:SolidMolecular weight:455.53Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Formula:C34H46N6O6SPurity:99.52%Color and Shape:SolidMolecular weight:666.83PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Color and Shape:Odour SolidTibesaikosaponin V
CAS:<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Formula:C42H68O15Color and Shape:SolidMolecular weight:812.98PPARγ/GR modulator 1
<p>PPARγ/GR Modulator 1, an orally active dual agonist for the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Glucocorticoid Receptor (GR), exhibits</p>Formula:C14H10FNO4Color and Shape:SolidMolecular weight:275.23TUG-499
CAS:<p>TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors</p>Formula:C16H11Cl2NO2Purity:99.93%Color and Shape:SoildMolecular weight:320.17PARP/HDAC-IN-1
<p>PARP/HDAC-IN-1 is a PARP and HDAC inhibitor that inhibits PARP1, PARP2, and HDAC1, and may be used to study pancreatic cancer.</p>Formula:C36H32F2N6O3Purity:95.00%Color and Shape:SolidMolecular weight:634.67Sibiromycin
CAS:<p>Sibiromycin: natural, potent antitumor PBD that binds DNA's minor groove at guanine NH2.</p>Formula:C24H33N3O7Color and Shape:SolidMolecular weight:475.542Hippeastrine Hydrobromide
CAS:<p>Hippeastrine hydrobromide is a natural alkaloid which demonstrates significant cytotoxicity against a panel of human and murine tumor cell lines.</p>Formula:C17H18BrNO5Color and Shape:SolidMolecular weight:396.237AZD-5099
CAS:<p>AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection.</p>Formula:C21H27Cl2N5O6SColor and Shape:SolidMolecular weight:548.44GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Formula:C25H31N7OSColor and Shape:SolidMolecular weight:477.62Sulotroban
CAS:<p>sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.</p>Formula:C16H17NO5SPurity:98.86% - 99.88%Color and Shape:SolidMolecular weight:335.37Ciprofibrate impurity A
CAS:<p>Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate is a PPARα agonist[1].</p>Formula:C12H14O3Color and Shape:SolidMolecular weight:206.241Antitumor agent-28
CAS:<p>Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.</p>Formula:C25H32N6O4SColor and Shape:SolidMolecular weight:512.631-O-Hexadecyl-Rac-Glycerol
CAS:<p>1-O-Hexadecyl-Rac-Glycerol (1-O-Hexadecylglycerol) is a marine derived natural products found in Tritoniella belli.</p>Formula:C19H40O3Purity:99.94%Color and Shape:SolidMolecular weight:316.52Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Formula:C17H15FN2OPurity:99.63%Color and Shape:SolidMolecular weight:282.31Becatecarin
CAS:<p>Becatecarin, water-soluble and anti-cancer, inhibits topoisomerases I/II and induces DNA cleavage and apoptosis; has myelosuppressive effects; ABCG2 substrate.</p>Formula:C33H34Cl2N4O7Color and Shape:SolidMolecular weight:669.56
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