Metabolism

<p>CRAC intermediate 1 (5-(S)-Fluorowillardiine) is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors.</p>

<p>Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). High-Quality, Low-Cost!</p>

<p>TH1760 inhibits NUDT15 (IC50=25nM); boosts 6-thioguanine efficacy in leukemia by raising 6-thio-(d)GTP.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rabbit PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rabbit PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rabbit PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>HIF-PHD-IN-3 is a hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.</p>

<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>

<p>SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).</p>

<p>Ciraparantag acetate reverses anticoagulation, binding heparins and DOACs noncovalently.</p>

<p>Oteseconazole (VT-1161) is an orally active anti-fungal agent.</p>

<p>Miglustat (NB-DNJ), derived from deoxynojirimycin, inhibits glucosylceramide synthase to manage Gaucher disease Type I.</p>

<p>RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)</p>

<p>Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.</p>

<p>EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.</p>

<p>Dehydro Nifedipine (BAY-b 4759), main human plasma nifedipine metabolite, blocks glucose in PC-12 cells, IC50 at 130 μM, forms via CYP3A4/3A5.</p>

<p>Diminazene is a trypanocidal agent.</p>

<p>Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.</p>

<p>Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.</p>

<p>Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.</p>

<p>Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>trans-C75 ((±)-C75) is an enantiomer of C75. C75 is an inhibitor of fatty-acid synthase (FASN).</p>

<p>Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of</p>

<p>Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES.</p>

<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>

<p>MM0299 is brain permeable, has anti-glioblastoma activity, inhibits lanosterol synthase (LSS), and induces EPC production in in situ GBM tumors.</p>

<p>Bis(4-cyanophenyl)methanol (4, 4'-Dicyanobenzhydrol) is a metabolite of Letrozole.</p>

<p>Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.</p>

<p>Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.</p>

<p>3-Methylindolin-2-one (3-Methyloxindole) is a reactant for O-acetylation reactions, enantioselective α-amination reactions and for aldol reactions.</p>

<p>MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.</p>

<p>SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.</p>

<p>N-Carbethoxy-4-piperidone is an aminopyrimidine derivative, compositions containing them and there served as pharmaceuticals.</p>

<p>Bifonazole (Bay H-4502) inhibits fungal enzyme cytochrome p450 51, halting ergosterol synthesis, causing cell membrane damage and fungal cell lysis.</p>

<p>Mildronate dihydrate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.</p>

<p>10,11-Dihydrocarbamazepine (Dihydrocarbamazepine) is used as pharmaceutical intermediates.</p>

<p>Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.</p>

<p>Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>Hematin (Ferrihemic acid) is an iron-containing porphyrin.</p>

<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>

<p>GSK-7975A is a potent and orally available inhibitor of CRAC channel.</p>

<p>Cyclandelate (BS 572), a direct-acting smooth muscle relaxant, is used to dilate blood vessels.</p>

<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>

<p>Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide.</p>

<p>Cefdinir (FK-482), a semi-synthetic third-gen cephalosporin antibiotic, treats ear, sinus, throat, and skin infections.</p>

<p>Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues.</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>Dafadine-A, a dafadine analog, inhibits DAF-9 P450 in C. elegans and mammalian CYP27A1.</p>

<p>CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor.</p>

<p>Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.</p>

<p>5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. It can be used in the preparation of disease-modifying antirheumatic drugs (DMARDs).</p>

<p>NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.</p>

<p>Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.</p>

<p>Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility.</p>

<p>5-R-Rivaroxaban is the (R)-enantiomer of Rivaroxaban, a potent FXa inhibitor with IC50 0.7 nM and Ki 0.4 nM.</p>

<p>Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.</p>

<p>Pyrithioxin (Encefabol), a nootropic, enhances cerebral metabolism and, with HV, aids hemiplegic stroke recovery.</p>

<p>Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.</p>

<p>2-(Hydroxymethyl)pyridine (Piconol) is an intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.</p>

<p>Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.</p>

<p>Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) relaxes arterioles and lowers blood pressure in mice.</p>

<p>MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT.</p>

<p>GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).</p>

<p>4-Desmethoxy Omeprazole, active Omeprazole metabolite, is a PPI that inhibits CYP2C19 (Ki: 2-6μM).</p>

<p>Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.</p>

<p>N-Desethyl Chloroquine Hydrochloride ((±)-Desethylchloroquine 2HCl) is a desethylchloroquine derivative.</p>

<p>Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.</p>

<p>Trimethoprim (NSC-106568) inhibits dihydrofolate reductase, CYP2C8, and OCT2 - an antibacterial agent.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and reduces thrombosis in research.</p>

<p>Diltiazem hydrochloride (RG 83606 HCl) is a benzothiazepine calcium channel blocking agent with vasodilating action.</p>

<p>3-Pyridylacetic acid HCl (3-PAA) is a strong acid, reactive with amines/alcohols/acids, and an organic catalyst.</p>

<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>

<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>

<p>Adrenochrome (Adraxone), an epinephrine derivative, is cytotoxic, has cardiotoxic effects, and may aid neuro-disease research.</p>

<p>Boc-LRR-AMC TFA is a fluorogenic protease substrate for detecting trypsin-like activity in the 26S proteasome or 20S proteasome core.</p>

<p>ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).</p>

<p>LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).</p>

<p>Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.</p>

<p>Managlinat dialanetil (MB06322) is an orally available fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for type 2 diabetes.</p>

<p>SHIP2-IN-1 is a potent SHIP2 inhibitor(IC50 : 2 µM),and used in the research of Alzheimer’s disease.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂，对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。</p>

<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>

<p>CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).</p>

<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>

<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>

<p>PEP 3 CHA: a carbohydrate metabolite with cytoprotection and antioxidant properties; cell membrane permeable.</p>

<p>VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; &gt;1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.</p>

<p>JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM).</p>

<p>SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.</p>

<p>Mefentrifluconazole: potent, selective oral fungicide; strong CYP51 blocker, weaker on human aromatase; novel azole for broad-spectrum use.</p>

<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>

<p>Ethylvanillin (Rhodiarome) is a flavorant used in the production of chocolate. It is about three times as potent as vanillin.</p>

<p>Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.</p>

<p>Oxolamine citrate (AF-438 citrate) is a cough suppressant that is able to be used as a generic drug in many jurisdictions.</p>

<p>Sucralose (Trichlorosucrose), an artificial sweetener, is not degraded by the body, so it is noncaloric.</p>

<p>Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.</p>

<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>