Organometallic Ligands

<p>GSK 137647A is an investigational pharmaceutical compound, which is a selective agonist sourced from GlaxoSmithKline's research laboratories. Its mode of action involves the stimulation of beta-3 adrenergic receptors, which are primarily located in adipose tissue and, notably, in cardiac tissue. This receptor activation leads to increased lipolysis and thermogenesis in adipose tissues, while in the cardiac tissue, it modulates heart function.</p>

<p>Lyn peptide inhibitor is a targeted peptide-based inhibitor derived synthetically to interact specifically with the Lyn kinase signaling pathway. As a research tool, it serves to elucidate the functional dynamics of Lyn kinase, which belongs to the Src family of tyrosine kinases involved in signal transduction processes critical to cellular differentiation, proliferation, and survival.</p>

<p>KP372-1 is a selective inhibitor that is synthetically derived. This compound functions by targeting and interfering with specific signaling pathways involved in cell growth and survival. Its inhibitory action primarily affects pathways such as PI3K/Akt, which are integral to the processes of cellular proliferation and apoptosis.</p>

<p>FK 102 CO(III) PF6 is a cobalt(III) complex salt, which is a coordination compound utilized extensively in organometallic chemistry and catalysis. Derived from cobalt, a transition metal known for its diverse oxidation states and coordination abilities, this compound is synthesized through the combination of cobalt with specific ligands, resulting in a hexafluorophosphate salt. The mode of action of this complex involves its ability to facilitate electron transfer processes, making it an excellent catalyst for various organic reactions.</p>

<p>ZJ 43 is an advanced biochemical compound that serves as a precision-targeted reagent, specifically designed for cellular and molecular biology applications. Derived from synthetic organic chemistry techniques, it features a high degree of purity and specificity, allowing it to interact with cellular proteins without significant off-target effects.</p>

<p>FN-1501 is a synthetic bioactive compound, which is engineered through combinatorial chemistry with a specific focus on enzymatic activity. This product has been meticulously designed to emulate protease-like activity, facilitating the cleavage of peptide bonds within protein substrates. The mode of action involves the catalytic hydrolysis of peptide bonds, thereby enabling the precise dissection of protein structures for analytical studies.</p>

<p>18:1 BDP (S,S) is a synthetic lipid compound, which is derived from the combination of a saturated phospholipid backbone and a desaturated aliphatic chain. This compound is meticulously engineered to incorporate two stereochemically specific chiral centers, which significantly influence its interaction with biological membranes. The source of this compound lies in the precise chemical synthesis techniques employed to achieve the desired stereochemistry.</p>

<p>(3S)-1-Cyano-N-[5-(4-morpholinyl)-2-thiazolyl]-3-pyrrolidinecarboxamide is a small molecule pharmaceutical compound that acts as a kinase inhibitor. Originating from advanced synthetic chemistry efforts, it is designed to modulate specific cellular pathways through its interaction with protein kinases. Its mode of action involves binding to the ATP-binding site of target kinases, thereby inhibiting their phosphorylation activity and subsequent signal transduction pathways.</p>

<p>Please enquire for more information about HKI 357 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PF 05105679 is an investigational pharmaceutical compound developed by Pfizer, classified as a selective nicotinic acetylcholine receptor (nAChR) antagonist. It is synthesized through meticulous organic chemistry techniques, representing a targeted approach to modifying neural pathways. The compound functions by selectively inhibiting specific subtypes of nAChRs, which are ligand-gated ion channels integral to synaptic transmission and neurophysiological processes.</p>

<p>Pythidc is a fungal inhibitor, which is derived from naturally occurring compounds with antimicrobial properties. This compound is isolated from specific plant metabolites through a series of extraction and purification processes. Its mode of action involves disrupting the cell membrane integrity of pathogenic fungi, thereby inhibiting their growth and proliferation. By targeting essential components of the fungal cell structure, Pythidc interferes with cell membrane synthesis and function, leading to cell lysis.</p>

<p>RG7800 is a small molecule inhibitor, which is a product synthesized through advanced organic chemistry processes. Its mode of action involves the selective binding to specific proteins within cellular pathways, effectively inhibiting their function. This is achieved through high-affinity interactions that alter the conformational states of targeted molecules, thereby impeding their biological activity.</p>

<p>Glyt1 inhibitor 1 is a chemical compound that acts as an inhibitor of the GlyT1 transporter, which is a product of synthetic chemistry. This inhibitor binds selectively to the glycine transporter-1 (GlyT1), a key protein responsible for the reuptake of glycine, an important neurotransmitter, in the central nervous system. By inhibiting GlyT1, this compound increases glycine levels in synaptic clefts, which can enhance N-methyl-D-aspartate (NMDA) receptor activity.</p>

<p>GW 583340 Dihydrochloride is a selective antagonist primarily targeting the G protein-coupled receptor 55 (GPR55), which is a type of membrane receptor implicated in various physiological and pathological processes. It is synthesized through complex organic chemical processes involving specific assembly of molecular components to achieve high specificity and efficiency in receptor binding.</p>

<p>ARP 101 is an advanced molecular compound designed for gene regulation research, which is synthesized from a highly refined organic substrate. Its mode of action involves binding to specific gene sequences, acting as a transcriptional modulator to either enhance or inhibit the expression of target genes. This is achieved through its precise interaction with transcriptional machinery and epigenetic factors, providing scientists with a powerful tool for elucidating mechanisms of gene expression and regulation.</p>

<p>AP5 is a selective NMDA receptor antagonist, which is a synthetic compound with critical applications in neuroscientific research. This compound is derived from a series of structural modifications to achieve selective binding to the NMDA receptor. AP5 functions by competitively inhibiting the glutamate binding site on the NMDA receptor, thereby blocking the receptor's ability to allow calcium influx into the neuron. This action is essential for its role in studies investigating neural signaling, plasticity, and excitotoxicity.</p>

<p>Linerixibat is an investigational pharmaceutical compound classified as an ileal bile acid transporter (IBAT) inhibitor. It is derived from chemical synthesis and acts by selectively targeting the IBAT, also known as the apical sodium-dependent bile acid transporter (ASBT), located in the distal ileum of the small intestine. By inhibiting this transporter, Linerixibat reduces the reabsorption of bile acids from the intestinal lumen, which leads to increased fecal bile acid excretion and reduced systemic levels of bile acids.</p>

<p>02:0 Coenzyme A is a specialized biochemical reagent utilized in scientific research. It is synthesized through enzymatic reactions involving pantothenic acid, cysteamine, and adenosine triphosphate (ATP) under controlled laboratory conditions. The compound is conjugated with specific fatty acid chains, making it a key intermediate in the metabolism of these molecules.</p>

<p>WAY 127093B racemate is a small organic compound, which is a synthesized chemical product with selective inhibitory properties. It is designed to target the cyclooxygenase-2 (COX-2) enzyme, which is primarily sourced through organic synthesis in laboratory settings, rather than being naturally derived. The mechanism of action involves specific blockade of the COX-2 enzyme, which plays a crucial role in catalyzing the conversion of arachidonic acid to prostaglandins. These prostaglandins are mediators of inflammation, pain, and fever. By inhibiting COX-2, WAY 127093B racemate effectively reduces the production of pro-inflammatory prostaglandins while sparing cyclooxygenase-1 (COX-1) pathways, which are important for gastric and renal function.</p>

<p>Esomeprazole magnesium salt is an enantiomerically pure proton pump inhibitor, which is derived from the class of compounds known as benzimidazoles. It is a synthetic compound, sourced through chemical synthesis that provides chirally-selective therapeutic effects. Through its mode of action, this compound specifically targets and irreversibly inhibits the H+/K+ ATPase enzyme situated on the gastric parietal cells, effectively blocking the final step of acid production in the stomach.</p>

<p>UR 1102 is a chemical compound used primarily in biomedical research, sourced from synthetic chemical processes. It operates as a selective modulator with the ability to interact with targeted biological pathways or receptors, depending on its specific design and formulation. The mode of action includes binding to particular sites, thereby influencing signaling cascades or biochemical processes within the system.</p>

<p>MK 0893 is a synthetic compound that acts as a liver X receptor (LXR) antagonist, which is derived from targeted drug discovery efforts focusing on nuclear receptor modulation. Its mode of action involves competitively inhibiting ATP binding at the LXR, effectively reducing the receptor's transcriptional activity. LXRs are nuclear receptors that regulate cholesterol, fatty acid, and glucose homeostasis by modulating gene expression.</p>

<p>BMS-911543 is a selective inhibitor of cyclin-dependent kinases (CDKs), which is a product of Bristol-Myers Squibb. It originates from extensive research aiming to target the dysregulated cell cycle processes often found in cancer cells. BMS-911543 works by inhibiting specific CDKs, which are crucial regulators of cell cycle progression, particularly affecting CDK2 and CDK9. This mode of action interferes with the cyclin-CDK complex's ability to phosphorylate target substrates, ultimately inducing cell cycle arrest and promoting apoptosis in susceptible cancer cells.</p>

<p>GMC 1-161 is a specialized biochemical compound, acting as a mitochondrial function modulator, which is synthetically derived with high precision. Its primary mode of action involves the targeted inhibition of the mitochondrial electron transport chain, particularly affecting complexes I and III. This inhibition results in altered ATP synthesis and increased production of reactive oxygen species, which are critical mechanisms for studying cellular respiration and oxidative stress pathways.</p>

<p>Mitoquinol is a potent antioxidant compound, which is a synthetic derivative of coenzyme Q10, with a mitochondria-targeted mechanism of action. It is designed to accumulate selectively within mitochondria, the powerhouses of the cell, by linking the antioxidant moiety to a triphenylphosphonium cation. This lipophilic cation facilitates the compound's swift uptake into mitochondria driven by the organelle's large membrane potential.</p>

<p>5-TAMRA-alkyne is a fluorescent dye, which is a synthetic compound derived from tetramethylrhodamine and equipped with an alkyne functional group. It operates through a fluorescence emission mechanism, where it absorbs light at a specific wavelength and re-emits it at a longer wavelength, allowing for visualization under specific conditions.</p>

<p>ML324 is a selective small-molecule modulator, which is a synthetically derived compound with the capacity to regulate molecular pathways. Specifically, it acts as an inhibitor of autophagy, a cellular degradation process critical for maintaining homeostasis.</p>

<p>Hepsulfam is an antitumor chemotherapy drug, which is a synthetic agent derived from the class of alkylating compounds. Its source lies in the chemical modification of nitrogen mustards, and it functions by forming interstrand cross-links in DNA, leading to the disruption of DNA replication and transcription. By preventing the proper division of cancerous cells, Hepsulfam exerts cytotoxic effects primarily during the S-phase of the cell cycle.</p>

<p>(-)-Nyasol is a naturally occurring lignan, which is a type of phytoestrogen found in certain plant species. It is primarily sourced from the roots of Anemarrhena asphodeloides, a herb widely used in traditional medicine. The compound exhibits its effects through modulation of estrogen receptors, demonstrating selective binding affinity that influences various estrogen-mediated pathways.</p>

<p>Sphinganine-d7 is a stable isotope-labeled analog of sphinganine, which is a bioactive lipid used extensively in biochemistry and molecular biology. This compound is derived from the natural sphingolipid backbone, with six deuterium atoms incorporated to facilitate tracking and measurement in scientific studies. The mode of action involves its role as a precursor in the biosynthesis of more complex sphingolipids, which are crucial components of cell membranes and play a role in signaling pathways.</p>

<p>Cdc42/Rac1 GTPase Inhibitor, ML141, is a small molecule inhibitor, which is a synthetic compound specifically designed to interfere with cellular processes. Originating from high-throughput screening and medicinal chemistry optimization, this inhibitor functions by selectively targeting the Rho family of GTPases, specifically Cdc42 and Rac1. These GTPases play crucial roles in regulating the actin cytoskeleton, cell movement, and growth signaling pathways.</p>

<p>BC-DXI-843 is an innovative biochemical compound, which is a synthesized molecule derived from advanced organic synthesis techniques. This compound functions through a specific binding interaction with target cellular proteins, modulating their activity for precise biological outcomes. Its mode of action involves the alteration of protein conformation, which subsequently influences downstream signaling pathways and cellular responses.</p>

<p>AMG 2850 is an investigational monoclonal antibody, which is derived from recombinant DNA technology with a specific mode of action targeting cancer cells. This therapeutic agent functions by binding to specific antigens expressed on the surface of malignant cells, thereby activating immune-mediated cytotoxic mechanisms or blocking signaling pathways crucial for tumor growth and survival. The precision of this antibody in targeting cancer cell antigens minimizes its impact on healthy cells, reducing potential side effects typically associated with broader-spectrum chemotherapies.</p>

<p>BAY 57-1293 is an antiviral agent, specifically classified as a helicase-primase inhibitor. It is derived from synthetic sources, developed by Bayer. Its mode of action involves inhibiting the helicase-primase complex of the Herpes Simplex Virus (HSV), crucial for viral DNA replication. By targeting this complex, BAY 57-1293 effectively halts the replication process of the virus, thereby impeding its proliferation and infection capability.</p>

<p>ETP 45658 is a synthetic polymer composite, which is fabricated from a combination of organic monomers and inorganic fillers. This innovative material is produced through a controlled polymerization process that ensures a uniform distribution of fillers, enhancing its structural integrity. The polymer matrix acts as a reinforcing agent, providing enhanced thermal stability and mechanical strength.</p>

<p>Plerixafor-d4 is an isotopically-labeled compound, specifically a deuterium-labeled analog of plerixafor, which is a small-molecule antagonist of the C-X-C chemokine receptor type 4 (CXCR4). This synthetic compound is designed to facilitate studies in receptor binding and mechanism elucidation by providing a stable isotope label useful in pharmacokinetics and bioanalytical applications.</p>

<p>GNE-7915 tosylate is an investigational small molecule inhibitor, which is chemically synthesized, designed to target specific kinases involved in cancer pathways. As a product of rigorous medicinal chemistry, it is derived from sophisticated laboratory synthesis processes utilizing advanced chemical techniques aimed at optimizing specificity and potency.</p>

<p>NSC 162535 disodium is a synthetic compound, classified as a chemical agent. It is derived from chemical synthesis processes intended for research and experimental purposes. The compound acts through biochemical interactions that affect specific cellular pathways, making it of interest for a variety of investigative biological studies.</p>

<p>ARS-1620 is a small-molecule inhibitor, which is derived from advanced medicinal chemistry efforts focused on targeting specific oncogenic mutations. This compound is synthesized with the precise intent to address challenges posed by mutant KRAS G12C, a particularly intractable target given its prevalence in various cancers such as lung and colorectal cancers.</p>

<p>Aldose reductase-IN-1 is a potent and selective inhibitor, which is a synthetic small molecule with a specific mode of action aimed at targeting the aldose reductase enzyme. Originating from pharmacological research, this compound is designed to interfere directly with the enzyme's activity. Aldose reductase-IN-1 functions by binding to the active site of aldose reductase, thus preventing the reduction of glucose to sorbitol, a crucial step in the polyol pathway.</p>

<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>

<p>C11 TopFluor Phytosphingosine is a fluorescent lipid analog, which is derived from the naturally occurring bioactive lipid, phytosphingosine. This compound incorporates a fluorophore into its structure, facilitating the tracking and visualization of lipid behavior in biological systems through advanced imaging techniques. The structure, with a short yet distinct fluorescent tag, retains the key biological properties of phytosphingosine, thus allowing it to participate in cellular processes similarly to its natural counterpart.</p>

<p>16:0 PE-DTPA (Gd) is a gadolinium-based contrast agent, which is a modified phospholipid compound. It is derived from saturating phosphatidylethanolamine with gadolinium(III) diethylenetriaminepentaacetic acid (DTPA). This specialized molecular structure enables it to enhance the contrast in magnetic resonance imaging (MRI) due to gadolinium's paramagnetic properties, which significantly accelerate the relaxation rates of nearby hydrogen nuclei.</p>

<p>BMS 819881 is a synthetic chemical compound, classified as a pharmaceutical agent. This compound originates from synthetic processes in medicinal chemistry, developed as part of a structured drug discovery program. Its mode of action involves inhibiting specific molecular targets related to metabolic pathways, which are impactful in regulating physiological processes at the cellular level.</p>

<p>SR33805 is a synthetic investigational compound, which is primarily derived from chemical synthesis with potential cardiovascular applications. This compound functions as a calcium channel antagonist, targeting specific ion channels that regulate the influx of calcium ions in cardiac and smooth muscle cells. By modulating these ion channels, SR33805 can affect muscle contractility and vascular tone.</p>

<p>(RS)-butyryltimolol is a non-selective beta-adrenergic receptor antagonist, commonly known as a beta-blocker. This compound is a synthetic derivative of timolol, an established therapeutic agent with enhanced properties due to its butyrylation. The source of (RS)-butyryltimolol lies in its chemical synthesis, whereby modifications to the timolol structure yield a compound with potential refined pharmacokinetics and dynamics.</p>

<p>Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor that is used as adjunct therapy to manage symptoms of Parkinson’s disease. Although its precise mechanism is unknown, it is thought to be an inhibitor of COMT and allows for a greater reduction in the symptoms of Parkinson’s.</p>

<p>Mirin is a type of condiment, which is a sweet rice wine used predominantly in Japanese cuisine. It is derived from fermenting a mixture of steamed glutinous rice, cultured rice (koji), and distilled alcohol. This fermentation process yields a liquid with a distinct sweet flavor and moderately low alcohol content.</p>

<p>Ac-RYYRIK-NH2 TFA is a synthetic peptide, which is a chemical compound composed of amino acid sequences and synthesized for research purposes. This peptide is derived from protein sequences found in biological systems, enabling it to mimic natural biological functions. Its mode of action involves interacting with specific molecular targets within biochemical pathways, making it a useful tool in studying receptor binding, signal transduction, and protein-protein interactions.</p>

<p>ZCZ 011 is a synthetic compound, which is derived from an engineered biochemical process designed for high specificity in binding interactions. It operates primarily through a targeted mechanism that involves interaction with specific molecular targets, thereby modulating cellular pathways with precision. This specificity is achieved through the compound’s unique structural attributes that allow for selective affinity towards its intended molecular targets.</p>

<p>ML169 is a small-molecule inhibitor, which is chemically synthesized and acts as a selective modulator of transcription factors. Its mode of action primarily involves the disruption of specific protein-protein interactions that are crucial for the transcriptional activity of targeted transcription factors, thereby inhibiting their ability to initiate or regulate the transcription of genes. This selective interference allows for precise manipulation of gene expression, making ML169 an invaluable tool in elucidating the fundamental mechanisms of transcriptional regulation.</p>

<p>ATP-Red 1 is a fluorescent probe, which is a synthetic molecule that allows for the visualization and quantification of adenosine triphosphate (ATP) within live cells. This product is derived from benzothiazole, a heterocyclic compound, and it exploits the unique properties of this structure to detect ATP with high specificity. The mode of action of ATP-Red 1 involves a fluorescence enhancement mechanism, where its binding to ATP results in a significant increase in fluorescence intensity. This enables the direct monitoring of ATP dynamics in real-time.</p>

<p>Aligeron is a natural alkaloid compound, which is derived from specific plant sources known for their medicinal properties. This compound functions through the inhibition of inflammatory pathways, specifically targeting mediators involved in the inflammatory response. Aligeron disrupts the activity of enzymes and signaling molecules that precipitate inflammation, thereby modulating the immune response to reduce inflammation and promote healing.</p>

<p>Nfat transcription factor regulator-1 is a biochemical reagent, which is commonly derived from synthetic or recombinant sources. It functions by modulating the activity of NFAT (nuclear factor of activated T-cells) transcription factors, which are crucial in several cellular processes. Through its regulatory action, it influences NFAT's ability to translocate to the nucleus and bind DNA, effectively controlling the transcription of genes involved in immune responses and other cellular activities.</p>

<p>Kainic Acid is a potent neuroexcitant, which is derived from certain species of red algae such as Digenea simplex. It acts as an agonist of kainate receptors, a subtype of ionotropic glutamate receptors, leading to excitotoxicity through the influx of calcium ions and the overactivation of neuronal circuits. Kainic Acid's ability to induce seizures by mimicking the neurotransmitter glutamate makes it an invaluable tool in neuroscientific research.</p>

<p>N-Methoxysuccinyl-Ala-Ala-Pro-Met p-nitroanilide is a synthetic chromogenic substrate, which is typically utilized in biochemical assays to assess protease activity, particularly that of elastase-like enzymes. The product is derived from chemical synthesis in the laboratory, featuring a specific peptide sequence conjugated to the p-nitroanilide group.</p>

<p>BNC105 is an experimental vascular-disrupting agent, which is a synthetic small molecule with a focus on antitumor activity. BNC105 originates from a careful chemical synthesis process tailored to disrupt the formation of new blood vessels, known as angiogenesis, within tumors. Its primary mode of action involves targeting the tubulin within the endothelial cells that line the blood vessels, leading to rapid disassembly of microtubules. This disruption of the cytoskeleton results in the collapse of the tumor vasculature, effectively cutting off the blood supply to the tumor and thereby causing tumor hypoxia and necrosis.</p>

<p>Ilaprazole is a proton pump inhibitor, which is a synthetic derivative aimed at decreasing gastric acid secretion. It is primarily sourced from chemical synthesis involving benzimidazole derivatives. Ilaprazole functions by selectively inhibiting the H+/K+ ATPase enzyme system located at the gastric parietal cells. This mode of action leads to prolonged suppression of gastric acid secretion due to an extended plasma half-life, which in turn promotes a sustained therapeutic effect.</p>

<p>1-(2-Benzyl-5-methylpyrazol-3-yl)-3-(3,4-difluorophenyl)urea is a synthetic chemical compound, which is typically synthesized through a series of organic reactions involving substituted pyrazoles and urea derivatives. This compound is primarily sourced from laboratory synthesis using controlled conditions to ensure purity and stability. Its mode of action involves the inhibition of specific protein kinases, which are essential in various signaling pathways within cells. By targeting these enzymes, this compound can disrupt cell proliferation and induce apoptosis, making it a valuable tool in cancer research.</p>

<p>TAS-103 is an investigational anti-cancer drug, which is a synthetic compound with origins in advanced medicinal chemistry. It functions as a topoisomerase inhibitor with dual-action targeting both topoisomerase I and II enzymes. Topoisomerases are crucial for modulating DNA supercoiling during replication and transcription processes. By interfering with these enzymes, TAS-103 hinders the DNA replication machinery, leading to replication fork stalling and subsequent induction of DNA damage, which can trigger cell death.</p>

<p>Geldanamycin-biotin is a conjugate compound, which combines the naturally-derived antibiotic geldanamycin with biotin, a small molecule commonly used for labeling. Geldanamycin is sourced from the bacterium *Streptomyces hygroscopicus* and functions primarily as an inhibitor of Heat Shock Protein 90 (Hsp90), a molecular chaperone involved in stabilizing and folding many proteins essential for cancer cell survival and proliferation.</p>

<p>Inhibitor of B-Raf mutant (V600E); anti-neoplastic</p>

<p>GSK621 is a selective inhibitor, which is synthesized for research purposes in the modulation of enzymatic activity. This compound is sourced through synthetic chemical processes and designed to selectively target the phosphoinositide 3-kinase (PI3K) pathway. GSK621's mode of action involves the inhibition of the PI3K pathway, a critical signaling pathway involved in cellular functions such as growth, proliferation, and survival. By inhibiting this pathway, GSK621 can modulate aberrant signaling commonly observed in various cancers.</p>

<p>12:0 EPC (Cl salt) is a cationic surfactant, which is a synthetic amphiphilic compound. It is sourced from quaternary ammonium compounds, commonly known for their ability to disrupt microbial cell membranes. As a cationic surfactant, its mode of action involves the interaction with negatively charged components of cell membranes, leading to increased permeability and eventual cell lysis.</p>

<p>5-HT4 serotonin receptor antagonist; used to treat irritable bowel syndrome</p>

<p>TAK-071 is a small-molecule pharmaceutical compound designed to modulate neuronal signaling. It is derived from rigorous medicinal chemistry optimization processes aimed at discovering selective central nervous system agents. TAK-071 acts as a positive allosteric modulator of the muscarinic M1 receptor, which is a subtype of the acetylcholine receptor widely distributed in the brain. Its mode of action includes enhancing cholinergic neurotransmission through selective binding and modulation, thus amplifying the effects of endogenous acetylcholine without directly activating the receptor itself.</p>

<p>Pancoprida is a bioactive peptide, which is a synthetic compound derived from rational peptide design and combinatorial chemistry techniques. It functions through the modulation of specific receptor pathways, primarily targeting neuronal and inflammatory processes. Pancoprida exhibits high affinity for serotonin receptors, influencing neurotransmitter release and uptake, and also modulates certain cytokine pathways, thereby reducing inflammation.</p>

<p>TCS 3035 is a photoinitiator, which is derived from a well-characterized synthetic process involving specialized chemical synthesis. This compound operates through a mode of action that involves the absorption of ultraviolet (UV) radiation, leading to the generation of free radicals. These radicals initiate the polymerization of monomeric or oligomeric species in UV-curable formulations.</p>

<p>Please enquire for more information about MIND4-17 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>[Ala113]-MBP (104-118) is a synthetic peptide, which is derived from human myelin basic protein (MBP). It is used as a tool in neurobiological research to study demyelinating diseases such as multiple sclerosis. The peptide is synthesized by replacing the serine at position 113 with alanine in the MBP (104-118) sequence. This modification allows researchers to investigate the structural and functional roles of specific amino acids in interactions with cellular receptors or other proteins.</p>

<p>Selonsertib hydrochloride is a potent ASK1 (Apoptosis signal-regulating kinase 1) inhibitor, which is a targeted small molecule therapeutic derived from chemical synthesis. Its mode of action involves the inhibition of ASK1, a kinase enzyme involved in cellular apoptosis and inflammation pathways. Specifically, ASK1 is upstream in the MAPK signaling cascade that modulates oxidative stress responses, often implicated in various pathological states.</p>

<p>SKLB4771 (FLT3-IN-1) is a selective small molecule inhibitor predominantly known for targeting FLT3, a receptor tyrosine kinase implicated in various hematological malignancies. Originating from a structure-based design and optimization process, this compound functions by competitively inhibiting the ATP-binding site of FLT3, thereby obstructing its autophosphorylation and subsequent downstream signaling cascades.</p>

<p>BF 227 is a diagnostic compound, which is a synthetic amyloid-imaging agent used in positron emission tomography (PET) scans. It is derived from chemical synthesis, specifically designed to bind selectively to amyloid-beta plaques, a hallmark of Alzheimer's disease pathology. <br><br>The mode of action of BF 227 involves its ability to cross the blood-brain barrier and selectively bind to amyloid-beta deposits within the brain. Once administered, this compound exhibits high affinity to these plaques, allowing it to serve as a contrast agent in PET imaging. This binding is crucial as it illuminates areas of plaque accumulation, providing a visual representation of amyloid load and aiding in the diagnosis of Alzheimer’s.<br><br>BF 227 is primarily used in research and clinical settings to enable the non-invasive quantification of amyloid plaques in living patients. Its application is pivotal for early detection and differentiation of Alzheimer's disease from other forms of dementia. By providing insights into the extent of amyloid deposition, BF 227 assists in the evaluation of disease progression and the effectiveness of therapeutic interventions, thereby contributing significantly to Alzheimer's research and patient management.</p>

<p>MHP 133 is a complex enzyme and motor protein, intricately involved in cellular transport mechanisms. It is derived from eukaryotic cellular structures, specifically synthesized and purified from genetically modified strains of yeast. The complex functions through ATP hydrolysis to facilitate movement along microtubules, a critical aspect of intracellular transport.</p>

<p>LGB-321 HCl is a serotonergic receptor modulator, which is synthesized from artificial chemical precursors. Its mechanism of action involves the selective modulation of specific serotonin receptors, potentially altering neurotransmitter pathways associated with various psychiatric and neurological disorders. The modulation of these pathways is critical in understanding the role of serotonin in mood, anxiety, and cognitive functions.</p>

<p>UVI 3003 is a light stabilizer that functions as an ultraviolet (UV) absorber, primarily utilized in the protection of various materials from UV radiation. This product is synthesized from advanced chemical compounds designed to absorb UV light and prevent its transmission through the material. The mode of action involves converting UV radiation into harmless thermal energy, which is then dissipated, thereby protecting the underlying matrix from photodegradation.</p>

<p>N-[(E,2S,3R)-1,3-Dihydroxyhexadec-4-en-2-yl]hexadecanamide is a bioactive lipid molecule, which is a derivative of sphingolipids, commonly found in higher eukaryotes. Sphingolipids are crucial components of cell membranes and play significant roles in cellular signaling pathways. This specific compound exhibits a unique configuration with both hydroxyl and amide functionalities that contribute to its interaction with biological membranes and proteins.</p>

<p>XL228 is an advanced bioactive compound, which is a synthetic molecule designed to target specific cellular pathways by modulating gene expression. It is derived from a chemically engineered process, ensuring high specificity and purity. By selectively inhibiting or activating key signaling cascades within target cells, XL228 can effectively alter cellular function at a molecular level.</p>

<p>Pyr10 is an advanced catalytic agent, which is derived from modified zeolitic materials with high thermal stability and unique structural properties. Its mode of action involves facilitating pyrolytic reactions by providing active sites that enhance the breakdown of complex organic molecules into simpler compounds. This catalytic activity is primarily due to its porous structure and acid-base active centers, which promote efficient molecular interactions during thermal decomposition.</p>

<p>CH 275 is a synthetic chemical compound that functions as an insecticide, originating from advanced chemical synthesis processes. This compound exerts its effects primarily through contact action, disrupting essential biological pathways in targeted pest species. By inhibiting neurotransmitter activity at synaptic junctions, CH 275 effectively paralyzes and neutralizes insects upon application.</p>

<p>IWP-O1 is a small molecule inhibitor designed to target the Wnt signaling pathway, which is pivotal in regulating key processes in cellular development and growth. This compound is derived through synthetic chemistry, crafted to bind specifically to Porcupine, an O-acyltransferase essential for Wnt protein secretion. By inhibiting Porcupine, IWP-O1 effectively disrupts the downstream activity of Wnt ligands, offering precise control over Wnt-dependent signaling cascades.</p>

<p>LY367385 is a selective antagonist of the metabotropic glutamate receptor subtype 1 (mGluR1), originating from advanced pharmacological research. Its mode of action involves competitive inhibition at the glutamate binding site on mGluR1, effectively modulating synaptic transmission by decreasing receptor activity. This modulation interferes with glutamate-induced neuronal excitability, making LY367385 an invaluable tool in the exploration of glutamatergic signaling pathways.</p>

<p>JNJ-17203212 is a pharmacological compound, specifically a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. This compound is derived from synthetic chemical processes, emphasizing its role in modulating ion channel activity. The TRPV1 receptor is a non-selective cation channel expressed predominantly in sensory neurons.</p>

<p>((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol is a synthetic chemical compound, specifically a chiral aminocyclopentanol derivative. This compound is often synthesized in laboratories for research purposes. It originates from the manipulation of naphthalene derivatives, which are common in the study of bioactive molecules.</p>

<p>PIN1 human is a peptidyl-prolyl cis-trans isomerase enzyme, which is derived from human tissues and cellular extracts. This enzyme plays a critical role in the regulation of protein function through isomerization of specific serine/threonine-phosphorylated proline bonds. Its mode of action involves altering the conformation of phosphorylated proteins, affecting their stability, localization, and interaction with other cellular molecules.</p>

<p>N-1-(Fur-3-ylethyl)-N-hydroxyurea is a chemical compound, which is a synthetic molecule designed for research and potential therapeutic applications. It is derived from organic synthetic processes involving urea and furanyl derivatives. The mode of action for N-1-(Fur-3-ylethyl)-N-hydroxyurea typically involves the inhibition of specific enzymatic activities, potentially through the formation of stable complexes with metal ions or disruption of enzyme-substrate interactions, although detailed mechanistic studies might be needed to fully elucidate its biochemical pathways.</p>

<p>CLK1-IN-1 is a small molecule compound, specifically a selective inhibitor, which is synthesized in laboratory settings. This product targets CDC-like kinases (CLKs), particularly CLK1, which are a group of serine/threonine-protein kinases involved in the regulation of alternative splicing. CLK1-IN-1 functions by binding to the active site of CLK1, thereby inhibiting its kinase activity. This inhibition can modulate the splicing of pre-mRNA, which is crucial for understanding regulatory mechanisms in gene expression.</p>

<p>Calmodulin1, His tagged human, is a recombinant protein that is utilized as a research tool in biochemistry and molecular biology. This protein is sourced from human calmodulin, which is a calcium-binding messenger protein expressed ubiquitously in eukaryotic cells. It is engineered to include a histidine tag that facilitates its purification and detection through affinity chromatography techniques. The mode of action for Calmodulin1 involves its role as a calcium-binding protein that can undergo conformational changes upon binding calcium ions. This interaction enables it to modulate the activity of various target enzymes and proteins, thus playing a pivotal role in calcium signaling pathways.</p>

<p>Avenanthramide A is a bioactive compound, which is a type of polyphenolic alkaloid, derived from oats (Avena sativa). This naturally occurring molecule is known for its potent antioxidant properties, which function by neutralizing free radicals and reducing oxidative stress within biological systems. Avenanthramide A exerts significant anti-inflammatory effects through the inhibition of nuclear factor-kappa B (NF-κB) activation, a key regulator of inflammation and immune response.</p>

<p>3-Cyclopropyl-N-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]-2-thiophenemethanamine is a synthetic compound belonging to the class of bicyclic amines. Originating from advanced chemical synthesis processes, this compound is designed to interact with central nervous system receptors. Its primary mode of action involves the modulation of neurotransmitter pathways, which can influence various CNS activities.</p>