Acids and Synthetic Reagents

<p>Applications Calcium nitrate tetrahydrate is a chemical used in the manufacture of fertilizers.<br></p>

<p>Applications Ammonium Chloride is used as a main component and source of nitrogen in fertilizer.<br>References Crill, P. et al.: Soil Biol. Biochem., 26, 1331 (1994); Zaman, M. et al.: Biol. Fert. Soils, 29, 178 (1999);<br></p>

<p>Applications Arbutin is a glycosylated hydroquinone extracted from bearberry plant. Arbutin is a known inhibitor of tyrosinase, which in turn prevents the formation of melanin. Arbutin is often used as a skin-lightening agent in cosmetic products.<br>References Magnusson, B., et al.: J. Invest. Dermatol., 52, 268 (1969), Goodwin, B., et al.: Contact Dermatitis, 7, 248, (1981), ,Itoh, M., et al.: J. Dermatol., 9, 223 (1982), Sugimoto, K., et al.: Biol. Pharm. Bull., 24, 510 (2004)<br></p>

<p>Applications Potassium Cyanide, a reagent widely used in organic synthesis for the preparation of nitriles and carboxylic acids, particularly in the von Richter reaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kollenz, G. et al.: Org. Prep. Proc. Int., 12, 244 (1980); Subramanian, L. R.: Sci. Synth., 19, 173 (2004);<br></p>

<p>Applications Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton's tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).<br>References Byrd; et al. (2015). "Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia."; "AstraZeneca to buy Acerta for blood cancer drug". www.rsc.org. Chemistry World - Royal Society of Chemistry. Retrieved 24 December 2015.<br></p>

<p>Applications Brigatinib is a tyrosine kinase receptor Mer (MERTK) inhibitor and can be used in combination with epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancer.<br>References Yan, D.; et al.: U.S. Pat. Appl. Publ. 48 pp. Patent 2017 CODEN:USXXCO<br></p>

<p>Applications A combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>

<p>Stability Hygroscopic<br>Applications Benzalkonium chloride (cas# 63449-41-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Displays antibacterial properties due to the presence of the quaternary amine and the counter ion.<br>References Igalsbe, M. L. et al.; Bioorgan. Med. Chem Lett 19, 4984 (2009)<br></p>

<p>Applications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. &amp; Goa, K.: Drugs, 35, 448 (1988); Klotz, U. &amp; Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>

<p>Applications Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>

<p>Applications A cholinergic receptor involved in the production of gastric acid. Cholinergic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ohshiba, Y., et al.: Chem. Pharm. Bull., 43, 1067 (1995), Chen, S., et al.: J. Pharmacol. Exp. Ther., 313, 765 (2005), Nangle, M., et al.: Br. J. Pharmacol., 148, 423 (2006),<br></p>

<p>Applications Potassium persulfate is an inorganic compound that is a strong oxidant. It is used in organic reactions for polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garry, J. C., et al.: Bioorg. Med. Chem. Lett., 21, 4589 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Sulfide Nonahydrate is used as a reagent in the synthesis of surface functionalized cadmium sulfide quantum dots.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Veinot, J.G.C., et al.: Chem. Mater., 9, 2117 (1997)<br></p>

<p>Applications Urolithin M6 is an intestinal microbial metabolite of ellagitannins.<br>References Garcia-Villalba, R., et al.: J. Agr. Food Chem., 61, 8797 (2013);<br></p>

<p>Applications CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.<br>References Shishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006); Konopleva, M. et al.: Leukemia, 19, 1350 (2005); Deeb, D. et al.: Cancers, 2, 1779 (2010); Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011);<br></p>

<p>Applications (S)-2-Amino-4-methylpentanol is a starting material for the synthesis of aminopeptidase N and phospholipase A2 inhibitors.<br>References Fournié-Zaluski, M., et al.: J. Med. Chem., 35, 1259 (1992); Bennion, C., et al.: J. Med. Chem., 35, 2939 (1992)<br></p>

<p>Applications Mepindolol is a non-selective β-adrenoceptor blocking agent. Mepindolol is used in the treatment of glaucoma.<br>References Luque Otero, M. et al.: Br. J. Clin. Pharmacol., 17, 361 (1984); Beckmann, R. et al.: Arzneim.-Forsch., 36, 811 (1986);<br></p>

<p>Applications D-Menthol is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications (±)-trans-9,10-Epoxystearic Acid Methyl Ester is a useful synthetic intermediate. It is an intermediate used to prepare (±)-erythro- and (±)-threo-9,10-difluorostearic acids. It is also used to synthesize monofluorinated fatty acids.<br>References Tavasli, M., et al.: Chem. Commun., 11, 1226 (2002); Buist, P., et al.: J. Chem. Soc., 17, 2617 (1997);<br></p>

<p>Applications 4-Hydroxyquinolineis a hydroxylated quinoline derivative with antimicrobial activity. 4-Hydroxyquinoline showed growth-inhibitory effects against intestinal bacteria. 4-Hydroxyquinoline act as sacrificial scavengers of the photogenerated oxygen species and has been shown to prevent the photodegradation of riboflavin.<br>References Kim, Y.-M. et al.: Food Sci. Biotechnol., 15, 817 (2006); Criado, S. et al.: J. Photochem. Photobiol. B Biol., 71, 19 (2003):<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. &amp; Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)<br></p>

<p>Applications S-enantiomer of Epichlorohydrin, an important industrial chemical, is a bifunctional alkylating agent with the potential to form DNA cross-links. It is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Romano, K.P. et al.: Chem. Res. Toxicol., 20, 832 (2007); Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948);<br></p>

<p>Applications Cyclohexanepropanoic Acid is a small lead compound that possess potential antifungal properties and effective against candida albicans and sacchromyces cerevisiae.<br>References Pilehvar-Soltanahmadi, Y., et al.: Novelty in Biomedicine, 2, 47 (2014)<br></p>

<p>Applications Methoxyacetyl chloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications MK8722 is a systemic, direct pan-activator of AMP-activated protein kinase.<br>References Feng, Danqing, et al.: ACS Med. Chem. Let., 9(1), 39-44 (2018);Myers, Robert W., et al.: Science, 357(6350), 507-511 (2017)<br></p>

<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>

<p>Applications Calcium Carbonate is a common chemical reagent used in various organic reactions. It is used in the synthesis of small molecules which disrupt Wnp-dependent signalling in tissue regeneration and cancer. Also used in the preparation of non-cytotoxic, silver nanoparticle-polysaccharide nanocomposites shown to provide antimicrobial activity.<br>References Chen, B. et al.: Nat. Chem. Biol., 5, 100 (2009); Travan, A. et al.: Biomacromol., 10, 1429 (2009);<br></p>

<p>Applications Lifitegrast is used for the treatment of signs and symptons of dry eye diseases. It also Inhibites corneal inflammation that is capable of causing pains, blurred vision and ocular discomfort in sufferer.<br>References Holland, E. J., et al.: Curr. Med. Res. Opin., 32, 1759 (2016); Sun, Y., et al.: J. Ocul. Pharmacol. Ther., 29, 395 (2013);<br></p>

<p>Applications Labelled Vincristine. An antitumor alkaloid isolated from Vinca rosea Linn. An antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Burns, J.H., et al.: Anal. Profiles Drug Subs., 1, 463 (1972), Owellen, D., et al.: J. Med. Chem., 15, 894 (1972),<br></p>

<p>Applications Chromium(III) chloride is used as the precursor to many organochromium compounds. Phosphine complexes derived from CrCl3 catalyse the trimerization of ethylene to 1-hexene.<br>References Dixon, J., et al.: Advances in selective ethylene trimerisation – a critical overview” Journal of Organometallic Chemistry, 689, 3641 (2004); Zheng, F. et al: Coordination Chemistry Reviews, 251, 2056 (2007)<br></p>

<p>Applications A silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocking with trimethylsiloxy units. Commonly used in skin and hair products. Approximate M.W. 4000.<br>References Disapio, A. et al.: Int. J. Cosmet. Sci. 10, 75(1988)<br></p>

<p>Stability Light Sensitive<br>Applications Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),<br></p>

<p>Applications AZ7550 is an impurity of the drug Osimertinib (A808075). Osimertinib is a selective EGFR inhibitor (epidermal growth factor receptor), used in the treatments of nonsmall-cell lung cancer (NSCLC).<br>References Finlay, M.R.V., et al.: J. Med. Chem., 57, 8249 (2014);<br></p>

<p>Applications Rochelle’s Salt is a common chemical precipitant from in x-ray crystallography as well as a useful ingredient in Biuret’s Reagent, a useful tool in the measurement of protein concentration.<br>References Mulki, S. et al.: J. Ind. Soc. Periodont., 17, 42 (2013); Tam, A. et al.: Bioorg. Med. Chem., 17, 1055 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Fasudil Monohydrochloride Salt is a selective ROCK inhibitor.<br>References Kanazawa, I., et al.: Endocr. J., 57, 415-421 (2010); Ding, J., et al.: J. Neurochem., 114, 1619-1629 (2010); Li, Y., et al.: Med. Sci. Monit., 16, BR112-BR118 (2010); Fujimura, M., et al.: Toxicol. Appl. Pharmacol., 250, 1-9 (2011);<br></p>

<p>Applications SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.<br>References Milne, J. et al.: Nature, 450, 712 (2007);<br></p>

<p>Applications 4-Acetylbenzenesulfonyl Chloride is used as one of the substances for mutagenic and carcinogenic risk assessment of carboxylic and sulfonic acid halides as drug impurities. Also, acts as a reagent for the synthesis of (+)-Dehydroabietylamine derivatives which are targeted for triple-negative breast cancer treatment.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Amberg, A., et al.: Org. Process Res. Dev., 19, 1495 (2015); Ling, T., et al.: Eur. J. Med. Chem., 102, 13, (2015)<br></p>

<p>Applications Bromoacetic Acid is a relatively strong alkylating agent as well as a versatile building block used very commonly in organic synthesis. Bromoacetic acid has been shown to reversibly inhibit human erythrocyte carbonic anhydrase B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Song, C. et al.: J. Org. Synth., 74, 8980 (2009); Kramer, S.P. et al.: J. Nat. Cancer Inst., 31, 297 (1963); Whitney, P.L. et al.: Eur. J. Biochem., 16, 126 (1970);<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Orally active anthracycline; analog of Daunorubicin. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976), Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986), Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987), Villani, F., et al.: Eur. J. Cancer Clin. Oncol., 25, 13 (1989),<br></p>

<p>Applications Sodium methylsulfinate can be used to synthesize cyclooxygenase-2 inhibitors.<br>References Khanna, I. K., et al: J. Med. Chem. 40, 1619 (1997); Penning, T. D., et al.: J. Med. Chem 40, 1347 (1997)<br></p>

<p>Stability Light Sensitive<br>Applications (Z)-Mycophenolic acid is the Z-isomer of Mycophenolic acid (M831500), an antibiotic drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications (1,1'-Bis(diphenylphosphino)ferrocene)dichloropalladium-dichloromethane is used in the preparation of imidazoles, benzimidazoles, and tetrahydropyrimidines.<br>References Geden, J. et al.: J. Org. Chem., 78, 4158 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Sulfate is a chemical reagent with a wide variety of uses, ranging from filler in laundry detergents, to manufacture of textiles. Also used in the process of paper pulping.<br>References Quina, F. et al.: J. Phys. Chem., 99, 17028 (1995); Wartena, R. et al.: J. App. Electrochem., 32, 415 (2002);<br></p>

<p>Applications (Acetylacetonato)dicarbonylrhodium(I) involved in the preparation of rhodium chelating bisphosphate brigaded complex and use as hydroformylation catalysts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bondzic. B.P., et al.: J. Mol. Catal. A: Chem., 423, 472-477 (2016)<br></p>

<p>Applications Sodium Tetrachloroaurate(III) Dihydrate, is an essential chemical compound used in chemical synthesis as gold catalyst.<br></p>

<p>Applications Fundamental starting material for organic synthesis.Metabolite of dibromobenzene in urine of rabbit.<br>References Ruzo, L., et al.: J. Agric. Food Chem., 24, 291 (1976),<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580).<br>References Driven, H.A.A.M. et al.: Chem. BIol. Inter., 93, 185 (1994); Fenselau, C. et al.: Xenobiotica, 22, 1207 (1992);<br></p>

<p>Applications Grubbs Catalyst, 1st Generation is a ruthenium-based olefin metathesis catalyst.<br>References Rosen, E.L., et. al.: J. Organomet. Chem., 745 (2013)<br></p>

<p>Impurity Atomoxetine EP Impurity E<br>Applications (S)-(+)-Mandelic Acid (Atomoxetine EP Impurity E) is an antiseptic (urinary).<br>References Pessela, B., et al.: Enzyme Microb. Technol., 40, 310 (2007), Carrasco-Lopez, C., et al.: J. Biol. Chem., 284, 4365 (2009),<br></p>

<p>Applications 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (cas# 5807-14-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).<br>References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)<br></p>

<p>Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.<br>References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),<br></p>

<p>Applications Croscarmellose Sodiumis a super disintegrant used in pharmaceuticals in the synthesis of tablets for oral administration.<br>References Reddy, V. et al.: Asian J. Pharm. Anal. Med. Chem., 2, 1 (2014);<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications An antibacterial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications A mitotic kinesin inhibitor as novel anti-cancer agent. Used in the study of neurodegenerative diseases.<br>References Brown, K., et al.: J. Cell Biol., 125, 1303 (1994), Sharp, D., et al.: Nature, 407, 41 (2000), Sueishi, M., et al.: J. Biol. Chem., 275, 28888 (2000), Lee, Y., et al.: Biochem. J., 360, 549 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications 6-Amino-2-hydroxymethyl Hexan-1-ol (cas# 125162-81-4) is a compound useful in organic synthesis.<br>References Rubina, A., et al.: Anal. Biochem., 325, 92 (2004),<br></p>

<p>Applications BARIUM CARBONATE (cas# 513-77-9) is a useful research chemical.<br></p>

<p>Applications Vasodilator, used in treatments for angina.<br>References Miyamoto, S., et al.: Toxicol. Mech. Method., 19, 477 (2009), Perez-Reyes, E., et al.: J. Pharmacol. Exper. Ther., 328, 621(2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009),<br></p>

<p>Applications 3-(2-Hydroxyphenyl)Propionic Acid (cas# 495-78-3) is a useful research chemical.<br></p>

<p>Applications Magnesium Chloride Hexahydrate is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications 4-Aminobutylcarbamic Acid tert-Butyl Ester is used in the synthesis of iron chelators expressing antitumor activity. Also used in the synthesis of iron oxide nanoparticles which are used in cellular and small animal imaging.<br>References Corce, V. et al.: Bioconj. Chem., 25, 320 (2014); Stanicki, D. et al., J. mat. Chem. B. Mat. Biol. Med.: 2, 387 (2014);<br></p>

<p>Applications Gonadorelin Acetate is used in various agricultural and biological studies. It was used in the study of ovulation synchronization in dairy cows.<br>References Pursley, J., et al.: Theriogenology, 44, 915 (1995).<br></p>

<p>Applications N-(chloroacetoxy)succinimide is a N-hydroxysuccinimide ester of a simple carboxylic acid. N-(chloroacetoxy)succinimide is used in the preparation of organometallic complexes and other synthetic probes for the labeling of proteins.<br>References Salmain, M. et al.: Bioconj. Chem., 4, 425 (1993); Nonaka, H. et al.: J. AM. Chem. Soc., 129, 15777 (2007);<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications Synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM. This inhibition action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavlock, R., et al.: J. Environ. Pathol. Toxicol., 2, 751 (1979), Enan, E., et al.: Biochem. Pharmacol., 43, 1777 (1992), Tan, J., et al.: Mol. Biol., 32, 445 (2002),<br></p>

<p>Applications Chiral derivative of 3-Hydroxyisobutyrate.<br>References Waldmann, H., et al.: Bioorg. Med. Chem., 2, 477 (1994), Vonstein, V., et al.: J. Bacteriol., 177, 4540 (1995),<br></p>

<p>Stability Store in freezer<br>Applications Selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine.<br>References Yoon, C., et al.: Mol. Cancer Res., 7, 361 (2009), Giussani, P., et al.: J. Biol. Chem., 284, 5088 (2009), Chen-Quay, S., et al.: J. Pharm. Sci., 98, 606 (2009), Satoh, Y., et al.: J. Biochem., 145, 31 (2009),<br></p>

<p>Applications Ketanserin Tartrate is used in nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis for preventing a variety of diseases ranging from cancer to ischemic injury.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gohil, V. M., et al.: Nat. Biotechnol, 28, 249 (2010)<br></p>

<p>Applications Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br>Chemical Name: Ammonium iron(III) citrate (cas# 1185-57-5) is a useful research chemical.<br></p>

<p>Applications (S)-(+)-Propane-1,2-diol is a general reagent used in organic synthesis. (S)-(+)-Propane-1,2-diol is used in the synthesis of anti-tuberculosis agents inspired by BTZ043 for MDR resistant strains.<br>References Tiwari, R. et al.: ACS Med. Chem. Lett., 5, 587 (2014); Tiwari, R. et al.: J. Am. Chem. Soc., 135, 3539 (2013);<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in the synthesis of novel phosphorothioates and phosphorodithioates as cholinesterase inhibitor.<br>References Sussman, J., et al.: Science, 253, 872 (1991), Mallender, W., et al.: J. Biol. Chem 1999, 274, 8491,<br></p>

<p>Applications Cupriethylenediamine Hydroxide is used as a solvent for cellulose.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, L., et al.: J. Applied Polym. Sci., 126, E244 (2012); Shi, W., et al.: Ind. Eng. Chem. Res., 52, 586 (2013); Cyrot, J., et al.: Bulletin de l'Institut Textile de France, 18, 211 (1964)<br></p>

<p>Applications 2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.<br>References Kang, S., et al.: J. Med. Chem., 57, 5293 (2014);<br></p>

<p>Applications Toxic to some wild and domestic birds and mice. Molluscicidal activity<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References De Abreu, F. et al.; Bioorg. Med. Chem. 9, 659 (2001); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 14, 111 (1985); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 12, 355 (1983)<br></p>

<p>Applications Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity<br>References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010);<br></p>

<p>Applications KU 55933 is an ATM kinase inhibitor, which provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism, ultimately inhibiting calpain and cathepsin D.<br>References Chwastek, J.; Jantas, D.; Lason, W.: Int. J. Biochem. Cell Biol., 87, 38 (2017)<br></p>